Genes differentially expressed between tumor-derived TEMs and TAMs
| Gene . | Fold more . | Fold less . | ΔCt . | P . | Gene . | Fold more . | Fold less . | ΔCt . | P . |
|---|---|---|---|---|---|---|---|---|---|
| Up-regulated | |||||||||
| Cd163 | 15.8 | 6.3 | < .001 | Timp2 | 2.8 | 4.5 | < .01 | ||
| Lyve1 | 14.1 | 6.1 | < .001 | Plxnd1 | 2.8 | 6.2 | < .01 | ||
| Igf1 | 8.2 | 9.3 | < .001 | Efna1 | 2.7 | 12.6 | < .01 | ||
| Stab1 | 6.4 | 5.5 | < .001 | Slamf1 | 2.6 | 14.6 | < .05 | ||
| Mrc1 | 5.3 | 3.0 | < .001 | Fcgr3 | 2.6 | 3.1 | < .05 | ||
| Sema6d | 5.2 | 15.2 | < .001 | Angpt1 | 2.6 | 14.2 | < .05 | ||
| Nrp1 | 4.6 | 6.3 | < .001 | Sema3c | 2.6 | 12.3 | < .05 | ||
| Cxcl12 | 4.4 | 10.6 | < .001 | Timp3 | 2.5 | 12.2 | < .05 | ||
| Thbs3 | 4.3 | 12.1 | < .001 | Kit | 2.5 | 14.9 | < .05 | ||
| Cxcl13 | 4.3 | 5.1 | < .001 | Sdc2 | 2.5 | 9.1 | < .05 | ||
| Efnb2 | 4.2 | 12.9 | < .01 | Efnb1 | 2.5 | 12.0 | < .05 | ||
| Neo1 | 4.1 | 15.1 | < .01 | Cdh5 | 2.4 | 11.6 | < .05 | ||
| Plxna3 | 4.1 | 12.8 | < .001 | Plxnb2 | 2.4 | 6.3 | < .05 | ||
| Itga2 | 4.0 | 16.3 | < .05 | Il4ra | 2.3 | 5.1 | < .05 | ||
| Plxna1 | 3.6 | 8.1 | < .001 | Il10ra | 2.2 | 6.5 | < .05 | ||
| Msr2 | 3.5 | 4.4 | < .001 | Arg1 | 2.2 | 5.7 | < .05 | ||
| Tlr4 | 3.5 | 7.8 | < .01 | Hpse | 2.1 | 5.6 | < .05 | ||
| Plxna4 | 3.1 | 10.9 | < .01 | Serpinb2 | 2.1 | 9.8 | < .05 | ||
| Edg1 | 3.0 | 8.1 | < .01 | Itgb1 | 2.1 | 5.0 | < .05 | ||
| Fcgr2b | 2.9 | 3.9 | < .01 | ||||||
| Down-regulated | |||||||||
| Il1b | −6.6 | 2.4 | < .001 | Ptprc | −2.7 | 3.7 | < .01 | ||
| Ptgs2 | −5.0 | 5.5 | < .001 | Ctss | −2.7 | 0.8 | < .01 | ||
| Il4 | −4.0 | 12.0 | < .001 | Tgfb1 | −2.6 | 4.2 | < .05 | ||
| Nos2 | −3.9 | 8.8 | < .001 | Il18 | −2.6 | 8.2 | < .05 | ||
| Ccr7 | −3.8 | 7.6 | < .001 | Sell | −2.5 | 10.3 | < .05 | ||
| Il12a | −3.6 | 16.2 | < .01 | Ccr2 | −2.5 | 5.8 | < .05 | ||
| Smad7 | −3.6 | 8.2 | < .001 | Il12b | −2.5 | 11.8 | < .05 | ||
| Bcl2l1 | −3.2 | 6.6 | < .01 | Nfkb2 | −2.5 | 5.9 | < .05 | ||
| Stat4 | −3.1 | 10.7 | < .01 | Fas | −2.4 | 9.8 | < .05 | ||
| Tnf | −3.1 | 4.0 | < .01 | Gusb | −2.4 | 4.9 | < .05 | ||
| Il13 | −3.1 | 12.8 | < .01 | Smad3 | −2.4 | 9.0 | < .05 | ||
| Actb | −3.0 | 1.0 | < .01 | Socs1 | −2.4 | 6.6 | < .05 | ||
| Edn1 | −3.0 | 11.0 | < .01 | Bax | −2.4 | 6.2 | < .05 | ||
| Ccl5 | −3.0 | 4.3 | < .01 | Pgk1 | −2.4 | 4.1 | < .05 | ||
| H2-Ea | −3.0 | 5.1 | < .01 | Ski | −2.3 | 6.1 | < .05 | ||
| Vegfa | −2.9 | 4.5 | < .01 | Csf1 | −2.3 | 7.8 | < .05 | ||
| Il1a | −2.9 | 5.2 | < .01 | Ctla4 | −2.2 | 12.9 | < .05 | ||
| Cxcl10 | −2.8 | 2.9 | < .01 | Stat1 | −2.1 | 3.7 | < .05 | ||
| Cd80 | −2.8 | 9.1 | < .01 | Tnfrsf18 | −2.1 | 12.0 | < .05 | ||
| Ece1 | −2.7 | 13.1 | < .05 | Tbx21 | −2.1 | 12.1 | < .05 | ||
| Cxcl11 | −2.7 | 6.6 | < .01 | ||||||
| Gene . | Fold more . | Fold less . | ΔCt . | P . | Gene . | Fold more . | Fold less . | ΔCt . | P . |
|---|---|---|---|---|---|---|---|---|---|
| Up-regulated | |||||||||
| Cd163 | 15.8 | 6.3 | < .001 | Timp2 | 2.8 | 4.5 | < .01 | ||
| Lyve1 | 14.1 | 6.1 | < .001 | Plxnd1 | 2.8 | 6.2 | < .01 | ||
| Igf1 | 8.2 | 9.3 | < .001 | Efna1 | 2.7 | 12.6 | < .01 | ||
| Stab1 | 6.4 | 5.5 | < .001 | Slamf1 | 2.6 | 14.6 | < .05 | ||
| Mrc1 | 5.3 | 3.0 | < .001 | Fcgr3 | 2.6 | 3.1 | < .05 | ||
| Sema6d | 5.2 | 15.2 | < .001 | Angpt1 | 2.6 | 14.2 | < .05 | ||
| Nrp1 | 4.6 | 6.3 | < .001 | Sema3c | 2.6 | 12.3 | < .05 | ||
| Cxcl12 | 4.4 | 10.6 | < .001 | Timp3 | 2.5 | 12.2 | < .05 | ||
| Thbs3 | 4.3 | 12.1 | < .001 | Kit | 2.5 | 14.9 | < .05 | ||
| Cxcl13 | 4.3 | 5.1 | < .001 | Sdc2 | 2.5 | 9.1 | < .05 | ||
| Efnb2 | 4.2 | 12.9 | < .01 | Efnb1 | 2.5 | 12.0 | < .05 | ||
| Neo1 | 4.1 | 15.1 | < .01 | Cdh5 | 2.4 | 11.6 | < .05 | ||
| Plxna3 | 4.1 | 12.8 | < .001 | Plxnb2 | 2.4 | 6.3 | < .05 | ||
| Itga2 | 4.0 | 16.3 | < .05 | Il4ra | 2.3 | 5.1 | < .05 | ||
| Plxna1 | 3.6 | 8.1 | < .001 | Il10ra | 2.2 | 6.5 | < .05 | ||
| Msr2 | 3.5 | 4.4 | < .001 | Arg1 | 2.2 | 5.7 | < .05 | ||
| Tlr4 | 3.5 | 7.8 | < .01 | Hpse | 2.1 | 5.6 | < .05 | ||
| Plxna4 | 3.1 | 10.9 | < .01 | Serpinb2 | 2.1 | 9.8 | < .05 | ||
| Edg1 | 3.0 | 8.1 | < .01 | Itgb1 | 2.1 | 5.0 | < .05 | ||
| Fcgr2b | 2.9 | 3.9 | < .01 | ||||||
| Down-regulated | |||||||||
| Il1b | −6.6 | 2.4 | < .001 | Ptprc | −2.7 | 3.7 | < .01 | ||
| Ptgs2 | −5.0 | 5.5 | < .001 | Ctss | −2.7 | 0.8 | < .01 | ||
| Il4 | −4.0 | 12.0 | < .001 | Tgfb1 | −2.6 | 4.2 | < .05 | ||
| Nos2 | −3.9 | 8.8 | < .001 | Il18 | −2.6 | 8.2 | < .05 | ||
| Ccr7 | −3.8 | 7.6 | < .001 | Sell | −2.5 | 10.3 | < .05 | ||
| Il12a | −3.6 | 16.2 | < .01 | Ccr2 | −2.5 | 5.8 | < .05 | ||
| Smad7 | −3.6 | 8.2 | < .001 | Il12b | −2.5 | 11.8 | < .05 | ||
| Bcl2l1 | −3.2 | 6.6 | < .01 | Nfkb2 | −2.5 | 5.9 | < .05 | ||
| Stat4 | −3.1 | 10.7 | < .01 | Fas | −2.4 | 9.8 | < .05 | ||
| Tnf | −3.1 | 4.0 | < .01 | Gusb | −2.4 | 4.9 | < .05 | ||
| Il13 | −3.1 | 12.8 | < .01 | Smad3 | −2.4 | 9.0 | < .05 | ||
| Actb | −3.0 | 1.0 | < .01 | Socs1 | −2.4 | 6.6 | < .05 | ||
| Edn1 | −3.0 | 11.0 | < .01 | Bax | −2.4 | 6.2 | < .05 | ||
| Ccl5 | −3.0 | 4.3 | < .01 | Pgk1 | −2.4 | 4.1 | < .05 | ||
| H2-Ea | −3.0 | 5.1 | < .01 | Ski | −2.3 | 6.1 | < .05 | ||
| Vegfa | −2.9 | 4.5 | < .01 | Csf1 | −2.3 | 7.8 | < .05 | ||
| Il1a | −2.9 | 5.2 | < .01 | Ctla4 | −2.2 | 12.9 | < .05 | ||
| Cxcl10 | −2.8 | 2.9 | < .01 | Stat1 | −2.1 | 3.7 | < .05 | ||
| Cd80 | −2.8 | 9.1 | < .01 | Tnfrsf18 | −2.1 | 12.0 | < .05 | ||
| Ece1 | −2.7 | 13.1 | < .05 | Tbx21 | −2.1 | 12.1 | < .05 | ||
| Cxcl11 | −2.7 | 6.6 | < .01 | ||||||
The expression level of each gene in tumor-derived TEMs is indicated as fold-change versus TAMs. The ΔCt of each gene was calculated using β2m as endogenous control.