Partition of plasma tHcy variance according to clinical and genetic variables obtained by multiple stepwise linear regression analysis in the GAIT and PROCARDIS samples
| Category . | Category R2 . | |
|---|---|---|
| GAIT . | PROCARDIS . | |
| Age, sex, smoking, BMI, country | 0.188 | 0.063 |
| Plasma fibrinogen | 0.008 | 0.013 |
| eGFR | NA | 0.035 |
| MTHFR (rs1801133), MTR (rs1805087), MTRR (rs16879418), CBS (rs6586282) | 0.050 | 0.015 |
| CPS1 (rs7422339), MUT (rs4267943), NOX4 (rs11018628), DPEP1 (rs460879) | 0.002 | 0.011 |
| ZNF366 (rs7445013) | 0.038 | 0.009 |
| PTPRD (rs973117) | 0.013 | 0.005 |
| Total | 0.299 | 0.151 |
| Category . | Category R2 . | |
|---|---|---|
| GAIT . | PROCARDIS . | |
| Age, sex, smoking, BMI, country | 0.188 | 0.063 |
| Plasma fibrinogen | 0.008 | 0.013 |
| eGFR | NA | 0.035 |
| MTHFR (rs1801133), MTR (rs1805087), MTRR (rs16879418), CBS (rs6586282) | 0.050 | 0.015 |
| CPS1 (rs7422339), MUT (rs4267943), NOX4 (rs11018628), DPEP1 (rs460879) | 0.002 | 0.011 |
| ZNF366 (rs7445013) | 0.038 | 0.009 |
| PTPRD (rs973117) | 0.013 | 0.005 |
| Total | 0.299 | 0.151 |
BMI indicates body mass index; and NA, not available.