Cox regression models for OM, NRM, and relapse and logistic regression models for graft failure and aGVHD
| . | Univariate models . | Multivariate models* . | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OM† . | NRM† . | Graft failure† . | aGvHD 2-4‡ . | aGvHD 3-4‡ . | Relapse‡ . | OM† . | NRM† . | Graft failure† . | aGvHD 2-4‡ . | aGvHD 3-4‡ . | Relapse‡ . | |
| 10 of 10 allele-matched; HLA-DPB1 permissive | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 10 of 10 allele-matched; HLA-DPB1 nonpermissive | 2.04 (1.26-3.30) | 3.33 (1.58-7.01) | 5.79 (0.74-45.4) | 1.05 (0.52-2.11) | 1.82 (0.49-6.74) | 1.22 (0.69-2.16) | 2.12 (1.23-3.64) | 3.41 (1.45-8.02) | NA§ | 1.29 (0.58-2.87) | 1.82 (0.49-6.73) | NA‖ |
| P | .003 | .002 | .09 | .88 | .37 | .40 | .006 | .005 | .52 | .37 | ||
| 9 of 10 allele-matched; HLA-DPB1 permissive | 1.32 (0.72-2.40) | 2.48 (1.06-5.80) | 2.21 (0.19-25.1) | 1.83 (0.81-4.12) | 5.02 (1.31-19.2) | 1.21 (0.61-2.40) | 1.38 (0.71-2.69) | 2.14 (0.81-5.66) | NA§ | 1.75 (0.69-4.45) | 5.01 (1.31-19.2) | NA‖ |
| P | .36 | .04 | .52 | .14 | .02 | .58 | .33 | .12 | .24 | .02 | ||
| 9 of 10 allele-matched; HLA-DPB1 nonpermissive | 2.29 (1.42-3.69) | 4.18 (2.01-8.72) | 6.84 (0.88-52.9) | 1.86 (0.95-3.65) | 4.17 (1.21-14.4) | 1.25 (0.70-2.22) | 2.21 (1.28-3.80) | 3.69 (1.58-8.61) | NA§ | 2.11 (0.97-4.56) | 4.15 (1.20-14.3) | NA‖ |
| P | .001 | < .001 | .06 | .07 | .02 | .44 | .004 | .002 | .06 | .02 | ||
| No more than 8 of 10 allele-matched; HLA-DPB1 irrespective | 2.30 (1.43-3.71) | 3.93 (1.88-8.23) | 5.99 (0.76-47.0) | 1.78 (0.90-3.53) | 2.41 (0.67-8.68) | 1.30 (0.74-2.31) | 2.04 (1.18-3.54) | 3.06 (1.30-7.19) | NA§ | 2.13 (0.97-4.65) | 2.40 (0.66-8.65) | NA‖ |
| P | .001 | < .001 | .09 | .09 | .18 | .36 | .01 | .01 | .06 | .18 | ||
| . | Univariate models . | Multivariate models* . | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OM† . | NRM† . | Graft failure† . | aGvHD 2-4‡ . | aGvHD 3-4‡ . | Relapse‡ . | OM† . | NRM† . | Graft failure† . | aGvHD 2-4‡ . | aGvHD 3-4‡ . | Relapse‡ . | |
| 10 of 10 allele-matched; HLA-DPB1 permissive | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 10 of 10 allele-matched; HLA-DPB1 nonpermissive | 2.04 (1.26-3.30) | 3.33 (1.58-7.01) | 5.79 (0.74-45.4) | 1.05 (0.52-2.11) | 1.82 (0.49-6.74) | 1.22 (0.69-2.16) | 2.12 (1.23-3.64) | 3.41 (1.45-8.02) | NA§ | 1.29 (0.58-2.87) | 1.82 (0.49-6.73) | NA‖ |
| P | .003 | .002 | .09 | .88 | .37 | .40 | .006 | .005 | .52 | .37 | ||
| 9 of 10 allele-matched; HLA-DPB1 permissive | 1.32 (0.72-2.40) | 2.48 (1.06-5.80) | 2.21 (0.19-25.1) | 1.83 (0.81-4.12) | 5.02 (1.31-19.2) | 1.21 (0.61-2.40) | 1.38 (0.71-2.69) | 2.14 (0.81-5.66) | NA§ | 1.75 (0.69-4.45) | 5.01 (1.31-19.2) | NA‖ |
| P | .36 | .04 | .52 | .14 | .02 | .58 | .33 | .12 | .24 | .02 | ||
| 9 of 10 allele-matched; HLA-DPB1 nonpermissive | 2.29 (1.42-3.69) | 4.18 (2.01-8.72) | 6.84 (0.88-52.9) | 1.86 (0.95-3.65) | 4.17 (1.21-14.4) | 1.25 (0.70-2.22) | 2.21 (1.28-3.80) | 3.69 (1.58-8.61) | NA§ | 2.11 (0.97-4.56) | 4.15 (1.20-14.3) | NA‖ |
| P | .001 | < .001 | .06 | .07 | .02 | .44 | .004 | .002 | .06 | .02 | ||
| No more than 8 of 10 allele-matched; HLA-DPB1 irrespective | 2.30 (1.43-3.71) | 3.93 (1.88-8.23) | 5.99 (0.76-47.0) | 1.78 (0.90-3.53) | 2.41 (0.67-8.68) | 1.30 (0.74-2.31) | 2.04 (1.18-3.54) | 3.06 (1.30-7.19) | NA§ | 2.13 (0.97-4.65) | 2.40 (0.66-8.65) | NA‖ |
| P | .001 | < .001 | .09 | .09 | .18 | .36 | .01 | .01 | .06 | .18 | ||
NA indicates not applicable.
Multivariate models include sex, age, and CMV status of donor and patient, year of transplantation, use of ATG, disease group, stem cell source, conditioning regimen, and use of TBI.
TCE4-nonpermissive mismatches were considered in the combined group of GvH and HvG direction and confronted with permissive mismatches. Numbers were for 10 of 10 allele-matched pairs: n = 140 nonpermissive, n = 61 permissive; for 9 of 10 allele-matched pairs: n = 145 nonpermissive, n = 54 permissive; for ≤8 of 10 allele-matched pairs: n = 137.
TCE4-nonpermissive mismatches were considered only in the GvH direction and confronted with the combined group of TCE4-permissive mismatches and TCE4-nonpermissive mismatches in the HvG direction. Numbers were for 10 of 10 allele-matched pairs: n = 72 nonpermissive, n = 129 permissive; for 9 of 10 allele-matched pairs: n = 85 nonpermissive, n = 114 permissive; for ≤8 of 10 allele-matched pairs: n = 137.
Not applicable because the number of events in each subgroup was too limited to allow statistically meaningful analysis.
Not applicable because the P > .2 in univariate models.