Treatment exposure by cohort
| . | Once-weekly bortezomib, cohort no.: dose (n) . | Twice-weekly bortezomib, cohort no.: dose (n) . | |||||
|---|---|---|---|---|---|---|---|
| 1: 0.7 mg/m2 (n = 3) . | 2: 1.0 mg/m2 (n = 3) . | 3: 1.3 mg/m2 (n = 3) . | 4: 1.6 mg/m2 (n = 6) . | 5: 0.7 mg/m2 (n = 3) . | 6: 1.0 mg/m2 (n = 6) . | 7: 1.3 mg/m2 (n = 7) . | |
| Median no. of cycles received (range) | 8 (3-8) | 8 (3-8) | 8 (6-22) | 8 (1-13) | 10 (5-18) | 6.5 (3-8) | 2 (1-6) |
| Median dose intensity, mg/m2 per cycle (range) | 2.8 (2.7-2.8) | 4.0 (3.0-4.2) | 5.1 (4.6-5.2) | 6.1 (4.8-6.5) | 2.8 (2.1-3.2) | 4.0 (2.9-4.2) | 3.9 (2.0-5.2) |
| . | Once-weekly bortezomib, cohort no.: dose (n) . | Twice-weekly bortezomib, cohort no.: dose (n) . | |||||
|---|---|---|---|---|---|---|---|
| 1: 0.7 mg/m2 (n = 3) . | 2: 1.0 mg/m2 (n = 3) . | 3: 1.3 mg/m2 (n = 3) . | 4: 1.6 mg/m2 (n = 6) . | 5: 0.7 mg/m2 (n = 3) . | 6: 1.0 mg/m2 (n = 6) . | 7: 1.3 mg/m2 (n = 7) . | |
| Median no. of cycles received (range) | 8 (3-8) | 8 (3-8) | 8 (6-22) | 8 (1-13) | 10 (5-18) | 6.5 (3-8) | 2 (1-6) |
| Median dose intensity, mg/m2 per cycle (range) | 2.8 (2.7-2.8) | 4.0 (3.0-4.2) | 5.1 (4.6-5.2) | 6.1 (4.8-6.5) | 2.8 (2.1-3.2) | 4.0 (2.9-4.2) | 3.9 (2.0-5.2) |