Table 1

Small molecule inhibitors involved in the suppression of translation

DrugBinding SiteMechanism of actionReference(s)
Ribavirin 5′ methyl-7-GTP cap Competitive inhibitor of eIF4E binding to capped mRNA 29,30  
4EGI-1 eIF4G Competitive inhibitor of eIF4E binding to eIF4G 31,32  
GnRH-4EBP fusion peptide eIF4E Peptidomimetic inhibitor of eIF4E binding to eIF4G 35  
Rapamycin, analogs and derivatives FKBP-rapamycin-binding (FRB) domain of mTOR Inhibits recruitment of FKBP12 protein to mTOR Reviewed in 45  
Torin1 mTOR kinase domain Inhibition of ATP binding to kinase domain 34  
PP242 mTOR kinase domain Inhibition of ATP binding to kinase domain 62  
PP30 mTOR kinase domain Inhibition of ATP binding to kinase domain 62  
CGP57380 MNK kinase domain Inhibition of ATP binding to kinase domain 113,,–116  
DrugBinding SiteMechanism of actionReference(s)
Ribavirin 5′ methyl-7-GTP cap Competitive inhibitor of eIF4E binding to capped mRNA 29,30  
4EGI-1 eIF4G Competitive inhibitor of eIF4E binding to eIF4G 31,32  
GnRH-4EBP fusion peptide eIF4E Peptidomimetic inhibitor of eIF4E binding to eIF4G 35  
Rapamycin, analogs and derivatives FKBP-rapamycin-binding (FRB) domain of mTOR Inhibits recruitment of FKBP12 protein to mTOR Reviewed in 45  
Torin1 mTOR kinase domain Inhibition of ATP binding to kinase domain 34  
PP242 mTOR kinase domain Inhibition of ATP binding to kinase domain 62  
PP30 mTOR kinase domain Inhibition of ATP binding to kinase domain 62  
CGP57380 MNK kinase domain Inhibition of ATP binding to kinase domain 113,,–116  
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