Small molecule inhibitors involved in the suppression of translation
Drug . | Binding Site . | Mechanism of action . | Reference(s) . |
---|---|---|---|
Ribavirin | 5′ methyl-7-GTP cap | Competitive inhibitor of eIF4E binding to capped mRNA | 29,30 |
4EGI-1 | eIF4G | Competitive inhibitor of eIF4E binding to eIF4G | 31,32 |
GnRH-4EBP fusion peptide | eIF4E | Peptidomimetic inhibitor of eIF4E binding to eIF4G | 35 |
Rapamycin, analogs and derivatives | FKBP-rapamycin-binding (FRB) domain of mTOR | Inhibits recruitment of FKBP12 protein to mTOR | Reviewed in 45 |
Torin1 | mTOR kinase domain | Inhibition of ATP binding to kinase domain | 34 |
PP242 | mTOR kinase domain | Inhibition of ATP binding to kinase domain | 62 |
PP30 | mTOR kinase domain | Inhibition of ATP binding to kinase domain | 62 |
CGP57380 | MNK kinase domain | Inhibition of ATP binding to kinase domain | 113,,–116 |
Drug . | Binding Site . | Mechanism of action . | Reference(s) . |
---|---|---|---|
Ribavirin | 5′ methyl-7-GTP cap | Competitive inhibitor of eIF4E binding to capped mRNA | 29,30 |
4EGI-1 | eIF4G | Competitive inhibitor of eIF4E binding to eIF4G | 31,32 |
GnRH-4EBP fusion peptide | eIF4E | Peptidomimetic inhibitor of eIF4E binding to eIF4G | 35 |
Rapamycin, analogs and derivatives | FKBP-rapamycin-binding (FRB) domain of mTOR | Inhibits recruitment of FKBP12 protein to mTOR | Reviewed in 45 |
Torin1 | mTOR kinase domain | Inhibition of ATP binding to kinase domain | 34 |
PP242 | mTOR kinase domain | Inhibition of ATP binding to kinase domain | 62 |
PP30 | mTOR kinase domain | Inhibition of ATP binding to kinase domain | 62 |
CGP57380 | MNK kinase domain | Inhibition of ATP binding to kinase domain | 113,,–116 |