Table 1 HLA class I–associated... | American Society of Hematology

Table 1

HLA class I–associated polymorphisms within the TL9 epitope are observed in subtype C but not in subtype A viruses

	Subtype C			Subtype A
	Sequence	n	%	Sequence	n	%
B42⁻	TPQDLNTML	36	90.0	TPQDLNMML	30	75.0
B81⁻	------S--	2	5.0	I--------	2	5
	--S---S--	1	2.5	--G------	2	5
	--A------	1	2.5	------V--	2	5
				------T--	1	2.5
				--S------	1	2.5
				--H------	1	2.5
				I-H------	1	2.5
B81⁺	TPQDLNTML	1	14.3	TPQDLNMML	8	88.9
	------S--	4	57.1	--G------	1	11.1
	--S---S--	2	28.6
B42⁺	TPQDLNTML	6	42.9	TPQDLNMML	8	66.7
	--T------	4	28.6	------T--	2	16.7
	--S---S--	2	14.3	--S------	1	8.3
	--A------	1	7.1	I--------	1	8.3
	--G------	1	7.1

	Subtype C			Subtype A
	Sequence	n	%	Sequence	n	%
B42⁻	TPQDLNTML	36	90.0	TPQDLNMML	30	75.0
B81⁻	------S--	2	5.0	I--------	2	5
	--S---S--	1	2.5	--G------	2	5
	--A------	1	2.5	------V--	2	5
				------T--	1	2.5
				--S------	1	2.5
				--H------	1	2.5
				I-H------	1	2.5
B81⁺	TPQDLNTML	1	14.3	TPQDLNMML	8	88.9
	------S--	4	57.1	--G------	1	11.1
	--S---S--	2	28.6
B42⁺	TPQDLNTML	6	42.9	TPQDLNMML	8	66.7
	--T------	4	28.6	------T--	2	16.7
	--S---S--	2	14.3	--S------	1	8.3
	--A------	1	7.1	I--------	1	8.3
	--G------	1	7.1

Shown are plasma virus TL9 epitope sequences isolated from 122 HIV-infected East Africans from Kenya and Tanzania. The TL9 epitope sequences are grouped into either subtype A or subtype C and then further subdivided according to the presence or absence of the TL9-presenting HLA class I molecules B42 and B81 in the infected host.

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