Patient and cord blood characteristics
| Variable . | Value . |
|---|---|
| No. of patients | 163 |
| Median age, y (range) | 55 (17-79) |
| Sex: male/female, no. of patients | 98/65 |
| Primary diseases, no. of patients | |
| Acute lymphoblastic leukemia | 20 |
| Acute myeloid leukemia | 63 |
| Chronic myelogenous leukemia | 5 |
| Myelodysplastic syndrome | 12 |
| Malignant lymphoma | 39 |
| Adult T-cell leukemia/lymphoma | 18 |
| Multiple myeloma | 2 |
| Others | 4 |
| Risk of underlying disease, no. of patients: standard/high | 32/131 |
| Preparative regimens, no. of patients | |
| Flu + Mel + TBI 2-8 Gy | 135 |
| Flu + BU + TBI 4-8 Gy | 18 |
| Flu + Mel | 6 |
| Flu + BU | 4 |
| Median no. of infused nucleated cells, 107/kg (range) | 2.68 (1.82-4.83) |
| Median no. of infused CD34+ cells, 105/kg (range) | 0.76 (0.05-4.40) |
| Blood-type mismatch, no. of patients: match/mismatch | 47/116 |
| HLA antigen mismatch, no. of patients | |
| 0 | 3 |
| 1 | 24 |
| 2 | 136 |
| GVHD prophylaxis, no. of patients | |
| Cyclosporine A alone | 73 |
| Tacrolimus alone | 90 |
| Variable . | Value . |
|---|---|
| No. of patients | 163 |
| Median age, y (range) | 55 (17-79) |
| Sex: male/female, no. of patients | 98/65 |
| Primary diseases, no. of patients | |
| Acute lymphoblastic leukemia | 20 |
| Acute myeloid leukemia | 63 |
| Chronic myelogenous leukemia | 5 |
| Myelodysplastic syndrome | 12 |
| Malignant lymphoma | 39 |
| Adult T-cell leukemia/lymphoma | 18 |
| Multiple myeloma | 2 |
| Others | 4 |
| Risk of underlying disease, no. of patients: standard/high | 32/131 |
| Preparative regimens, no. of patients | |
| Flu + Mel + TBI 2-8 Gy | 135 |
| Flu + BU + TBI 4-8 Gy | 18 |
| Flu + Mel | 6 |
| Flu + BU | 4 |
| Median no. of infused nucleated cells, 107/kg (range) | 2.68 (1.82-4.83) |
| Median no. of infused CD34+ cells, 105/kg (range) | 0.76 (0.05-4.40) |
| Blood-type mismatch, no. of patients: match/mismatch | 47/116 |
| HLA antigen mismatch, no. of patients | |
| 0 | 3 |
| 1 | 24 |
| 2 | 136 |
| GVHD prophylaxis, no. of patients | |
| Cyclosporine A alone | 73 |
| Tacrolimus alone | 90 |
Flu indicates fludarabine; Mel, melphalan; TBI, total body irradiation; and BU, busulfan.