Univariate analyses of engraftment kinetics according to HLA disparity
No. of HLA mismatches . | Neutrophil engraftment . | ||||
---|---|---|---|---|---|
n . | Cumulative incidence, % . | Median day . | Range . | P . | |
HLA-A, -B, -DR (antigen) | .09 | ||||
0 + 1 | 23 | 91 | 17 | 11-30 | |
2 | 129 | 89 | 20 | 11-55 | |
HLA-A, -B, -DR (antigen, HVG) | .4 | ||||
0 + 1 | 43 | 93 | 19 | 11-55 | |
2 | 109 | 87 | 20 | 11-49 | |
HLA-A, -B, -DR (antigen, GVH) | < .001 | ||||
0 + 1 | 53 | 96 | 19 | 11-36 | |
2 | 99 | 85 | 20 | 11-55 | |
HLA-A, -B (class I antigen) | .1 | ||||
0 | 13 | 92 | 17 | 12-30 | |
1 | 86 | 91 | 20 | 11-44 | |
2 | 53 | 85 | 20 | 11-55 | |
HLA-A, -B (class I antigen, HVG) | .4 | ||||
0 | 22 | 96 | 18 | 12-36 | |
1 | 86 | 89 | 20 | 11-55 | |
2 | 44 | 84 | 20 | 11-49 | |
HLA-A, -B (class I antigen, GVH) | .006 | ||||
0 | 23 | 95 | 17.5 | 11-36 | |
1 | 88 | 91 | 20.5 | 11-44 | |
2 | 41 | 81 | 20 | 12-55 | |
HLA-A (antigen) | .7 | ||||
0 | 87 | 89 | 19 | 11-44 | |
1 + 2 | 65 | 89 | 20 | 11-55 | |
HLA-A (antigen, HVG) | .8 | ||||
0 | 96 | 89 | 20 | 11-55 | |
1 + 2 | 56 | 89 | 20 | 11-49 | |
HLA-A (antigen, GVH) | .2 | ||||
0 | 103 | 90 | 19 | 11-44 | |
1 + 2 | 49 | 86 | 20 | 13-55 | |
HLA-B (antigen) | .07 | ||||
0 | 36 | 94 | 19 | 12-34 | |
1 + 2 | 116 | 87 | 20 | 11-55 | |
HLA-B (antigen, HVG) | .06 | ||||
0 | 45 | 95 | 19 | 12-36 | |
1 + 2 | 107 | 86 | 20 | 11-55 | |
HLA-B (antigen, GVH) | .04 | ||||
0 | 42 | 95 | 18.5 | 11-36 | |
1 + 2 | 110 | 86 | 20 | 11-55 | |
HLA-DR (antigen) | .4 | ||||
0 | 70 | 87 | 20 | 11-55 | |
1 + 2 | 82 | 90 | 19.5 | 11-44 | |
HLA-DR (antigen, HVG) | .7 | ||||
0 | 76 | 88 | 20 | 11-55 | |
1 + 2 | 76 | 89 | 20 | 11-44 | |
HLA-DR (antigen, GVH) | .8 | ||||
0 | 83 | 88 | 20 | 11-55 | |
1 + 2 | 69 | 90 | 20 | 11-44 | |
HLA-A, -B (antigen), -DR (allele) | .5 | ||||
0 + 1 | 13 | 92 | 18 | 14-30 | |
2 | 63 | 84 | 20 | 11-47 | |
3 + 4 | 44 | 86 | 20 | 11-49 | |
HLA-A, -B (antigen, HVG), -DR (allele, HVG) | .2 | ||||
0 + 1 | 25 | 96 | 18 | 11-32 | |
2 | 54 | 80 | 20 | 11-44 | |
3 + 4 | 41 | 90 | 20 | 11-49 | |
HLA-A, -B (antigen, GVH), -DR (allele, GVH) | .05 | ||||
0 + 1 | 26 | 96 | 18 | 11-36 | |
2 | 57 | 84 | 19.5 | 11-49 | |
3 + 4 | 37 | 84 | 20 | 11-34 | |
HLA-A, -B, -DR (allele) | .4 | ||||
0 + 1 | 10 | 90 | 18 | 14-30 | |
2 | 36 | 86 | 20 | 11-44 | |
3 + 4 + 5 | 56 | 84 | 19 | 11-49 | |
HLA-A, -B, -DR (allele, HVG) | .3 | ||||
0 + 1 | 19 | 94 | 19 | 11-32 | |
2 | 34 | 79 | 20 | 13-44 | |
3 + 4 + 5 | 49 | 86 | 21 | 11-49 | |
HLA-A, -B, -DR (allele, GVH) | .05 | ||||
0 + 1 | 16 | 94 | 17 | 11-30 | |
2 | 40 | 88 | 20 | 11-44 | |
3 + 4 + 5 | 46 | 80 | 20 | 11-49 |
No. of HLA mismatches . | Neutrophil engraftment . | ||||
---|---|---|---|---|---|
n . | Cumulative incidence, % . | Median day . | Range . | P . | |
HLA-A, -B, -DR (antigen) | .09 | ||||
0 + 1 | 23 | 91 | 17 | 11-30 | |
2 | 129 | 89 | 20 | 11-55 | |
HLA-A, -B, -DR (antigen, HVG) | .4 | ||||
0 + 1 | 43 | 93 | 19 | 11-55 | |
2 | 109 | 87 | 20 | 11-49 | |
HLA-A, -B, -DR (antigen, GVH) | < .001 | ||||
0 + 1 | 53 | 96 | 19 | 11-36 | |
2 | 99 | 85 | 20 | 11-55 | |
HLA-A, -B (class I antigen) | .1 | ||||
0 | 13 | 92 | 17 | 12-30 | |
1 | 86 | 91 | 20 | 11-44 | |
2 | 53 | 85 | 20 | 11-55 | |
HLA-A, -B (class I antigen, HVG) | .4 | ||||
0 | 22 | 96 | 18 | 12-36 | |
1 | 86 | 89 | 20 | 11-55 | |
2 | 44 | 84 | 20 | 11-49 | |
HLA-A, -B (class I antigen, GVH) | .006 | ||||
0 | 23 | 95 | 17.5 | 11-36 | |
1 | 88 | 91 | 20.5 | 11-44 | |
2 | 41 | 81 | 20 | 12-55 | |
HLA-A (antigen) | .7 | ||||
0 | 87 | 89 | 19 | 11-44 | |
1 + 2 | 65 | 89 | 20 | 11-55 | |
HLA-A (antigen, HVG) | .8 | ||||
0 | 96 | 89 | 20 | 11-55 | |
1 + 2 | 56 | 89 | 20 | 11-49 | |
HLA-A (antigen, GVH) | .2 | ||||
0 | 103 | 90 | 19 | 11-44 | |
1 + 2 | 49 | 86 | 20 | 13-55 | |
HLA-B (antigen) | .07 | ||||
0 | 36 | 94 | 19 | 12-34 | |
1 + 2 | 116 | 87 | 20 | 11-55 | |
HLA-B (antigen, HVG) | .06 | ||||
0 | 45 | 95 | 19 | 12-36 | |
1 + 2 | 107 | 86 | 20 | 11-55 | |
HLA-B (antigen, GVH) | .04 | ||||
0 | 42 | 95 | 18.5 | 11-36 | |
1 + 2 | 110 | 86 | 20 | 11-55 | |
HLA-DR (antigen) | .4 | ||||
0 | 70 | 87 | 20 | 11-55 | |
1 + 2 | 82 | 90 | 19.5 | 11-44 | |
HLA-DR (antigen, HVG) | .7 | ||||
0 | 76 | 88 | 20 | 11-55 | |
1 + 2 | 76 | 89 | 20 | 11-44 | |
HLA-DR (antigen, GVH) | .8 | ||||
0 | 83 | 88 | 20 | 11-55 | |
1 + 2 | 69 | 90 | 20 | 11-44 | |
HLA-A, -B (antigen), -DR (allele) | .5 | ||||
0 + 1 | 13 | 92 | 18 | 14-30 | |
2 | 63 | 84 | 20 | 11-47 | |
3 + 4 | 44 | 86 | 20 | 11-49 | |
HLA-A, -B (antigen, HVG), -DR (allele, HVG) | .2 | ||||
0 + 1 | 25 | 96 | 18 | 11-32 | |
2 | 54 | 80 | 20 | 11-44 | |
3 + 4 | 41 | 90 | 20 | 11-49 | |
HLA-A, -B (antigen, GVH), -DR (allele, GVH) | .05 | ||||
0 + 1 | 26 | 96 | 18 | 11-36 | |
2 | 57 | 84 | 19.5 | 11-49 | |
3 + 4 | 37 | 84 | 20 | 11-34 | |
HLA-A, -B, -DR (allele) | .4 | ||||
0 + 1 | 10 | 90 | 18 | 14-30 | |
2 | 36 | 86 | 20 | 11-44 | |
3 + 4 + 5 | 56 | 84 | 19 | 11-49 | |
HLA-A, -B, -DR (allele, HVG) | .3 | ||||
0 + 1 | 19 | 94 | 19 | 11-32 | |
2 | 34 | 79 | 20 | 13-44 | |
3 + 4 + 5 | 49 | 86 | 21 | 11-49 | |
HLA-A, -B, -DR (allele, GVH) | .05 | ||||
0 + 1 | 16 | 94 | 17 | 11-30 | |
2 | 40 | 88 | 20 | 11-44 | |
3 + 4 + 5 | 46 | 80 | 20 | 11-49 |