Genotype and allele frequencies of HPSE gene SNPs rs4693608 and rs4364254 and their combinations in recipients, donors, and control healthy persons
| SNP/SNP combination . | Genotype/allele . | Recipients . | Total donors . | Related donors . | Disparity, % . | Unrelated donors . | Disparity, % . | χ2/P . | Controls . |
|---|---|---|---|---|---|---|---|---|---|
| rs4693608 | AA | 30.4% (126) | 23.9% (87) | 22.5% (48) | 38.0 | 25.8% (39) | 59.6 | 16.5/< .001 | 25.0% (27) |
| AG | 48.3% (200) | 54.9% (200) | 55.4% (118) | 54.3% (82) | 57.41% (62) | ||||
| GG | 21.3% (88) | 21.2% (77) | 22.1% (47) | 19.9% (30) | 17.6% (19) | ||||
| A | 54.6% (452) | 51.4% (374) | 50.2% (214) | 53.0% (160) | 53.7% (116) | ||||
| G | 45.4% (376) | 48.6% (354) | 49.8% (212) | 47.0% (142) | 46.3% (100) | ||||
| rs4364254 | TT | 44.7% (185) | 41.8% (152) | 39.4% (84) | 35.1 | 45.0% (68) | 62.9 | 27.4/< .001 | 45.4% (49) |
| TC | 40.3% (167) | 45.3% (165) | 46.0% (98) | 44.4% (67) | 46.3% (50) | ||||
| CC | 15.0% (62) | 12.9% (47) | 14.6% (31) | 10.6% (16) | 8.3% (9) | ||||
| T | 64.9% (537) | 64.4% (469) | 62.4% (266) | 67.2% (203) | 68.5% (148) | ||||
| C | 35.1% (291) | 35.6% (259) | 37.6% (160) | 32.8% (99) | 31.5% (68) | ||||
| rs4693608 and rs4364254: | AA-TT, AA-TC | 30.4% (126) | 23.9% (87) | 22.5% (48) | 37.1 | 25.8% (39) | 63.6 | 24.8/< .001 | 25.0% (27) |
| HR | AG-TC, AG-TT | 42.5% (176) | 48.1% (175) | 48.4% (103) | 47.7% (72) | 52.8% (57) | |||
| MR LR | GG-CC, GG-TC, GG-TT, AG-CC | 27.1% (112) | 28.0% (102) | 29.1% (62) | 26.5% (40) | 22.2% (24) |
| SNP/SNP combination . | Genotype/allele . | Recipients . | Total donors . | Related donors . | Disparity, % . | Unrelated donors . | Disparity, % . | χ2/P . | Controls . |
|---|---|---|---|---|---|---|---|---|---|
| rs4693608 | AA | 30.4% (126) | 23.9% (87) | 22.5% (48) | 38.0 | 25.8% (39) | 59.6 | 16.5/< .001 | 25.0% (27) |
| AG | 48.3% (200) | 54.9% (200) | 55.4% (118) | 54.3% (82) | 57.41% (62) | ||||
| GG | 21.3% (88) | 21.2% (77) | 22.1% (47) | 19.9% (30) | 17.6% (19) | ||||
| A | 54.6% (452) | 51.4% (374) | 50.2% (214) | 53.0% (160) | 53.7% (116) | ||||
| G | 45.4% (376) | 48.6% (354) | 49.8% (212) | 47.0% (142) | 46.3% (100) | ||||
| rs4364254 | TT | 44.7% (185) | 41.8% (152) | 39.4% (84) | 35.1 | 45.0% (68) | 62.9 | 27.4/< .001 | 45.4% (49) |
| TC | 40.3% (167) | 45.3% (165) | 46.0% (98) | 44.4% (67) | 46.3% (50) | ||||
| CC | 15.0% (62) | 12.9% (47) | 14.6% (31) | 10.6% (16) | 8.3% (9) | ||||
| T | 64.9% (537) | 64.4% (469) | 62.4% (266) | 67.2% (203) | 68.5% (148) | ||||
| C | 35.1% (291) | 35.6% (259) | 37.6% (160) | 32.8% (99) | 31.5% (68) | ||||
| rs4693608 and rs4364254: | AA-TT, AA-TC | 30.4% (126) | 23.9% (87) | 22.5% (48) | 37.1 | 25.8% (39) | 63.6 | 24.8/< .001 | 25.0% (27) |
| HR | AG-TC, AG-TT | 42.5% (176) | 48.1% (175) | 48.4% (103) | 47.7% (72) | 52.8% (57) | |||
| MR LR | GG-CC, GG-TC, GG-TT, AG-CC | 27.1% (112) | 28.0% (102) | 29.1% (62) | 26.5% (40) | 22.2% (24) |