Univariate analysis of cumulative incidence of clinically significant (II-IV and III-IV) acute GVHD in association with HPSE gene SNPs and SNP combinations
| SNP/SNP combination . | Genotype/ genotype combination . | Cumulative incidence, % . | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Recipient . | Donor . | ||||||||||||
| II-IV . | 95% CI . | χ2/P . | III-IV . | 95% CI . | χ2/P . | II-IV . | 95% CI . | χ2/P . | III-IV . | 95% CI . | χ2/P . | ||
| rs4693608 | AA | 52.7 | 43.3-64.1 | 13.7/.001 | 40.9 | 31.4-53.3 | 18.7/< .001 | 35.6 | 26.1-48.5 | 4.8/.09 | 20.7 | 12.9-33.2 | .5/.78 |
| AG | 38.5 | 31.7-46.8 | 20.4 | 14.7-28.3 | 45.5 | 38.4-54.0 | 26.2 | 19.8-34.8 | |||||
| GG | 24.3 | 16.2-36.3 | 14.0 | 7.9-25.0 | 28.8 | 19.3-43.0 | 24.5 | 15.5-38.7 | |||||
| rs4364254 | TT | 41.9 | 34.5-50.8 | 4.4/.11 | 26.5 | 19.8-35.5 | 4.6/.098 | 41.0 | 33.3-50.6 | .34/.84 | 25.8 | 18.8-35.5 | .39/.82 |
| TC | 41.3 | 33.7-50.6 | 26.8 | 20.0-36.0 | 38.9 | 31.2-78.3 | 23.9 | 17.3-33.0 | |||||
| CC | 26.9 | 17.2-42.2 | 12.8 | 6.1-27.3 | 38.1 | 25.2-57.6 | 22.3 | 11.5-43.1 | |||||
| rs4693608 and rs4364254 | |||||||||||||
| HR | AA-TT, AA-TC | 54.4 | 44.7-66.2 | 18.6/< .001 | 42.7 | 32.8-55.5 | 23.3/< .001 | 36.1 | 26.5-49.1 | 1.3/.53 | 21.1 | 13.1-33.7 | .43/.81 |
| MR | AG-TC, AG-TT | 40.5 | 33.2-49.4 | 21.8 | 15.6-30.6 | 43.3 | 35.8-52.2 | 24.8 | 18.3-33.7 | ||||
| LR | GG-CC, GG-TC, GG-TT, AG-CC | 24.9 | 17.7-34.9 | 13.7 | 8.2-22.7 | 36.4 | 27.0-48.9 | 26.6 | 18.0-39.2 | ||||
| SNP/SNP combination . | Genotype/ genotype combination . | Cumulative incidence, % . | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Recipient . | Donor . | ||||||||||||
| II-IV . | 95% CI . | χ2/P . | III-IV . | 95% CI . | χ2/P . | II-IV . | 95% CI . | χ2/P . | III-IV . | 95% CI . | χ2/P . | ||
| rs4693608 | AA | 52.7 | 43.3-64.1 | 13.7/.001 | 40.9 | 31.4-53.3 | 18.7/< .001 | 35.6 | 26.1-48.5 | 4.8/.09 | 20.7 | 12.9-33.2 | .5/.78 |
| AG | 38.5 | 31.7-46.8 | 20.4 | 14.7-28.3 | 45.5 | 38.4-54.0 | 26.2 | 19.8-34.8 | |||||
| GG | 24.3 | 16.2-36.3 | 14.0 | 7.9-25.0 | 28.8 | 19.3-43.0 | 24.5 | 15.5-38.7 | |||||
| rs4364254 | TT | 41.9 | 34.5-50.8 | 4.4/.11 | 26.5 | 19.8-35.5 | 4.6/.098 | 41.0 | 33.3-50.6 | .34/.84 | 25.8 | 18.8-35.5 | .39/.82 |
| TC | 41.3 | 33.7-50.6 | 26.8 | 20.0-36.0 | 38.9 | 31.2-78.3 | 23.9 | 17.3-33.0 | |||||
| CC | 26.9 | 17.2-42.2 | 12.8 | 6.1-27.3 | 38.1 | 25.2-57.6 | 22.3 | 11.5-43.1 | |||||
| rs4693608 and rs4364254 | |||||||||||||
| HR | AA-TT, AA-TC | 54.4 | 44.7-66.2 | 18.6/< .001 | 42.7 | 32.8-55.5 | 23.3/< .001 | 36.1 | 26.5-49.1 | 1.3/.53 | 21.1 | 13.1-33.7 | .43/.81 |
| MR | AG-TC, AG-TT | 40.5 | 33.2-49.4 | 21.8 | 15.6-30.6 | 43.3 | 35.8-52.2 | 24.8 | 18.3-33.7 | ||||
| LR | GG-CC, GG-TC, GG-TT, AG-CC | 24.9 | 17.7-34.9 | 13.7 | 8.2-22.7 | 36.4 | 27.0-48.9 | 26.6 | 18.0-39.2 | ||||
Significant deviations (P < .05) are marked in bold.