Gene set enrichment analysis on KEGG pathways for H929 and SACHI cell lines after overexpression of the NIK or IKKβ genes
| . | H929 . | SACHI . | ||
|---|---|---|---|---|
| IKKβ vs none . | NIK vs none . | IKKβ vs none . | NIK vs none . | |
| In 4 of 4 transfectants | ||||
| Autoimmune thyroid disease | + | + | + | + |
| Allograft rejection | + | + | + | + |
| GVHD | + | + | + | + |
| Type 1 diabetes mellitus | + | + | + | + |
| Antigen processing and presentation | + | + | + | + |
| In 3 of 4 transfectants | ||||
| Cytokine–cytokine receptor interaction | + | + | − | + |
| Cell adhesion molecules (CAMs) | − | + | + | + |
| Asthma | − | + | + | + |
| In 2 of 4 transfectants | ||||
| MAPK signaling pathway | + | − | + | − |
| Toll-like receptor signaling pathway | + | − | − | + |
| Glycerophospholipid metabolism | − | + | + | − |
| Primary immunodeficiency | + | + | − | − |
| Alanine and aspartate metabolism | − | − | + | + |
| Tyrosine metabolism | − | − | + | + |
| Ether lipid metabolism | − | − | + | + |
| Limonene and pinene degradation | − | − | + | + |
| Hematopoietic cell lineage | − | − | + | + |
| Vibrio cholerae infection | − | − | + | + |
| Phenylalanine metabolism | − | − | + | + |
| In 1 of 4 transfectants | ||||
| Bile acid biosynthesis | + | − | − | − |
| Apoptosis | + | − | − | − |
| Antigen processing and presentation | + | − | − | |
| Natural killer cell–mediated cytotoxicity | + | − | − | − |
| T-cell receptor signaling pathway | + | − | − | − |
| B-cell receptor signaling pathway | + | − | − | − |
| Circadian rhythm | + | − | − | − |
| Adipocytokine signaling pathway | + | − | − | − |
| Small cell lung cancer | + | − | − | − |
| Glycerolipid metabolism | − | − | + | − |
| Porphyrin and chlorophyll metabolism | − | − | + | − |
| Alkaloid biosynthesis II | − | − | + | − |
| Biosynthesis of unsaturated fatty acids | − | − | + | − |
| Epithelial cell signaling in Hp infection | − | − | + | − |
| Systemic lupus erythematosus | − | − | + | − |
| Histidine metabolism | − | − | − | + |
| Urea cycle and metabolism of amino groups | − | − | − | + |
| Aminosugars metabolism | − | − | − | + |
| β-Alanine metabolism | − | − | − | + |
| Metabolism of xenobiotics by cytochrome | − | − | − | + |
| Toll-like receptor signaling pathway | − | − | − | + |
| . | H929 . | SACHI . | ||
|---|---|---|---|---|
| IKKβ vs none . | NIK vs none . | IKKβ vs none . | NIK vs none . | |
| In 4 of 4 transfectants | ||||
| Autoimmune thyroid disease | + | + | + | + |
| Allograft rejection | + | + | + | + |
| GVHD | + | + | + | + |
| Type 1 diabetes mellitus | + | + | + | + |
| Antigen processing and presentation | + | + | + | + |
| In 3 of 4 transfectants | ||||
| Cytokine–cytokine receptor interaction | + | + | − | + |
| Cell adhesion molecules (CAMs) | − | + | + | + |
| Asthma | − | + | + | + |
| In 2 of 4 transfectants | ||||
| MAPK signaling pathway | + | − | + | − |
| Toll-like receptor signaling pathway | + | − | − | + |
| Glycerophospholipid metabolism | − | + | + | − |
| Primary immunodeficiency | + | + | − | − |
| Alanine and aspartate metabolism | − | − | + | + |
| Tyrosine metabolism | − | − | + | + |
| Ether lipid metabolism | − | − | + | + |
| Limonene and pinene degradation | − | − | + | + |
| Hematopoietic cell lineage | − | − | + | + |
| Vibrio cholerae infection | − | − | + | + |
| Phenylalanine metabolism | − | − | + | + |
| In 1 of 4 transfectants | ||||
| Bile acid biosynthesis | + | − | − | − |
| Apoptosis | + | − | − | − |
| Antigen processing and presentation | + | − | − | |
| Natural killer cell–mediated cytotoxicity | + | − | − | − |
| T-cell receptor signaling pathway | + | − | − | − |
| B-cell receptor signaling pathway | + | − | − | − |
| Circadian rhythm | + | − | − | − |
| Adipocytokine signaling pathway | + | − | − | − |
| Small cell lung cancer | + | − | − | − |
| Glycerolipid metabolism | − | − | + | − |
| Porphyrin and chlorophyll metabolism | − | − | + | − |
| Alkaloid biosynthesis II | − | − | + | − |
| Biosynthesis of unsaturated fatty acids | − | − | + | − |
| Epithelial cell signaling in Hp infection | − | − | + | − |
| Systemic lupus erythematosus | − | − | + | − |
| Histidine metabolism | − | − | − | + |
| Urea cycle and metabolism of amino groups | − | − | − | + |
| Aminosugars metabolism | − | − | − | + |
| β-Alanine metabolism | − | − | − | + |
| Metabolism of xenobiotics by cytochrome | − | − | − | + |
| Toll-like receptor signaling pathway | − | − | − | + |
KEGG pathways induced by activation of classical or alternative NF-κB pathways in H929 and Sachi MMCL.