IDO1 inhibition reduces DC apoptosis and increases CD86high DCs
| . | Percentage viable, mean ± SD . | Percentage apoptotic, mean ± SD . | Percentage CD86high, mean ± SD . |
|---|---|---|---|
| DC | 49.9 ± 25.6 | 28.6 ± 11.3 | 32.9 ± 23.6 |
| DC + LPS | 18.9 ± 5.5 | 59.1 ± 3.3 | 32.3 ± 17.7 |
| DC + LPS + INCB024360 | 54.2 ± 5.9 | 33.7 ± 6.3 | 47.1 ± 15.9 |
| DC + PGN | 29.7 ± 3.3 | 43.7 ± 4.9 | 16.3 ± 7.5 |
| DC + PGN + INCB024360 | 68.1 ± 10.1 | 21.9 ± 9.6 | 42.1 ± 2.9 |
| . | Percentage viable, mean ± SD . | Percentage apoptotic, mean ± SD . | Percentage CD86high, mean ± SD . |
|---|---|---|---|
| DC | 49.9 ± 25.6 | 28.6 ± 11.3 | 32.9 ± 23.6 |
| DC + LPS | 18.9 ± 5.5 | 59.1 ± 3.3 | 32.3 ± 17.7 |
| DC + LPS + INCB024360 | 54.2 ± 5.9 | 33.7 ± 6.3 | 47.1 ± 15.9 |
| DC + PGN | 29.7 ± 3.3 | 43.7 ± 4.9 | 16.3 ± 7.5 |
| DC + PGN + INCB024360 | 68.1 ± 10.1 | 21.9 ± 9.6 | 42.1 ± 2.9 |
Values are mean ± SD of 3 independent experiments. INCB024360 was used at 1μM.
DC indicates dendritic cell; LPS, lipopolysaccharide; and PGN, peptidoglycan.