Clinical definitions required to confirm identified complications
| Complication . | Definition . |
|---|---|
| EMH | Radiologic evidence of extramedullary hematopoietic foci with or without symptoms |
| PHT | Systolic pulmonary artery pressure > 35 mm Hg, which corresponds to a tricuspid regurgitant velocity on Doppler echocardiography of > 2.8 m/s18 plus exertional dyspnea without evidence of left heart disease |
| HF | Modified Framingham criteria19 |
| Thrombosis | Compression ultrasonography, contrast venography, or angiography evidence of thrombus |
| Cholelithiasis | Ultrasonographic evidence of gallbladder stones |
| Abnormal liver function | ALT > 50 U/L |
| Leg ulcers | Ischemic or necrotic skin lesion on the lower extremity by general visual inspection |
| DM | Fasting blood sugar ≥ 126 mg/dL, or 2-hour postprandial blood sugar ≥ 200 mg/dL, or symptoms of hyperglycemia and a casual (random) plasma glucose ≥ 200 mg/dL20 |
| Hypothyroidism | TSH > 4.7 μU/L and a free T4 < 0.8 ng/dL21 |
| Osteoporosis | Bone densitometry T score: 2.5 SD22 |
| Hypogonadism | Females: > 13 y, not yet Tanner B2 (ie, prepubertal breast development) or > 14 y requiring estrogen replacement therapy or > 15 y with primary amenorrhea; males: > 14 y, not yet Tanner G2 (ie, prepubertal genital development) or on androgen replacement therapy or > 17 y, not yet Tanner G4 (ie, midpubertal genital development)23 |
| Complication . | Definition . |
|---|---|
| EMH | Radiologic evidence of extramedullary hematopoietic foci with or without symptoms |
| PHT | Systolic pulmonary artery pressure > 35 mm Hg, which corresponds to a tricuspid regurgitant velocity on Doppler echocardiography of > 2.8 m/s18 plus exertional dyspnea without evidence of left heart disease |
| HF | Modified Framingham criteria19 |
| Thrombosis | Compression ultrasonography, contrast venography, or angiography evidence of thrombus |
| Cholelithiasis | Ultrasonographic evidence of gallbladder stones |
| Abnormal liver function | ALT > 50 U/L |
| Leg ulcers | Ischemic or necrotic skin lesion on the lower extremity by general visual inspection |
| DM | Fasting blood sugar ≥ 126 mg/dL, or 2-hour postprandial blood sugar ≥ 200 mg/dL, or symptoms of hyperglycemia and a casual (random) plasma glucose ≥ 200 mg/dL20 |
| Hypothyroidism | TSH > 4.7 μU/L and a free T4 < 0.8 ng/dL21 |
| Osteoporosis | Bone densitometry T score: 2.5 SD22 |
| Hypogonadism | Females: > 13 y, not yet Tanner B2 (ie, prepubertal breast development) or > 14 y requiring estrogen replacement therapy or > 15 y with primary amenorrhea; males: > 14 y, not yet Tanner G2 (ie, prepubertal genital development) or on androgen replacement therapy or > 17 y, not yet Tanner G4 (ie, midpubertal genital development)23 |
ALT indicates alanine transaminase; DM, diabetes mellitus; TSH, thyroid stimulating hormone; and T4, thyroxine.