Respiratory and systemic symptoms associated with coronavirus or rhinovirus detection at time of virus detection or within the prior week
| Symptom . | Coronavirus . | Rhinovirus . | ||
|---|---|---|---|---|
| OR (95% CI) . | P . | OR (95% CI) . | P . | |
| Rhinorrhea | 1.4 (0.7-2.6) | .33 | 2.3 (1.3-4.1) | .004 |
| Sinus congestion | 0.9 (0.4-2.2) | .83 | 3.4 (1.8-6.9) | < .001 |
| Postnasal drip | 0.7 (0.3-1.6) | .38 | 2.4 (1.3-4.8) | .009 |
| Shortness of breath | 0.9 (0.3-2.8) | .79 | 1.5 (0.7-3.3) | .32 |
| Sputum | 0.9 (0.4-2.0) | .74 | 1.9 (1.1-3.3) | .03 |
| Pharyngitis | 0.8 (0.2-2.6) | .70 | 0.8 (0.4-1.7) | .61 |
| Sneezing | 0.8 (0.2-2.4) | .63 | 0.9 (0.5-1.8) | .88 |
| Cough | 1.9 (0.9-4.1) | .12 | 2.3 (1.3-4.2) | .006 |
| Wheezing* | — | — | 2.0 (0.8-5.1) | .16 |
| Fever | 0.8 (0.3-1.8) | .58 | 0.7 (0.4-1.2) | .22 |
| Headache | 0.9 (0.5-1.9) | .85 | 1.0 (0.6-1.7) | .99 |
| Myalgias | 0.3 (0.1-0.8) | .02 | 0.6 (0.3-1.3) | .22 |
| Diarrhea | 1.2 (0.6-2.5) | .55 | 0.7 (0.4-1.3) | .28 |
| Symptom . | Coronavirus . | Rhinovirus . | ||
|---|---|---|---|---|
| OR (95% CI) . | P . | OR (95% CI) . | P . | |
| Rhinorrhea | 1.4 (0.7-2.6) | .33 | 2.3 (1.3-4.1) | .004 |
| Sinus congestion | 0.9 (0.4-2.2) | .83 | 3.4 (1.8-6.9) | < .001 |
| Postnasal drip | 0.7 (0.3-1.6) | .38 | 2.4 (1.3-4.8) | .009 |
| Shortness of breath | 0.9 (0.3-2.8) | .79 | 1.5 (0.7-3.3) | .32 |
| Sputum | 0.9 (0.4-2.0) | .74 | 1.9 (1.1-3.3) | .03 |
| Pharyngitis | 0.8 (0.2-2.6) | .70 | 0.8 (0.4-1.7) | .61 |
| Sneezing | 0.8 (0.2-2.4) | .63 | 0.9 (0.5-1.8) | .88 |
| Cough | 1.9 (0.9-4.1) | .12 | 2.3 (1.3-4.2) | .006 |
| Wheezing* | — | — | 2.0 (0.8-5.1) | .16 |
| Fever | 0.8 (0.3-1.8) | .58 | 0.7 (0.4-1.2) | .22 |
| Headache | 0.9 (0.5-1.9) | .85 | 1.0 (0.6-1.7) | .99 |
| Myalgias | 0.3 (0.1-0.8) | .02 | 0.6 (0.3-1.3) | .22 |
| Diarrhea | 1.2 (0.6-2.5) | .55 | 0.7 (0.4-1.3) | .28 |
Results are for 195 of 215 patients. Nine patients with no symptom survey data and 11 patients with no data regarding seasonal allergies were excluded from these analyses. Each result was adjusted for the following covariates: other respiratory viruses within the last week, day relative to transplantation, age at transplantation, pretransplantation allergies, conditioning regimen, donor type, and grades 2 to 4 acute graft-versus-host disease.
— indicates not applicable.
There were too few occurrences of coronavirus to include as a predictor for wheezing. Ear pain and watery eyes were too rare for analysis.