Temporal sensitivity of MAPKs to glucocorticoids
| Ligand . | p38 MAPK . | JNK . | ERK . | |||
|---|---|---|---|---|---|---|
| Early . | Late . | Early . | Late . | Early . | Late . | |
| LPS | ++ | +++ | R | R | R | R |
| Poly (I:C) | ++ | + | + | +++ | + | +++ |
| CpG | ++ | +++ | R | R | +++ | + |
| Ligand . | p38 MAPK . | JNK . | ERK . | |||
|---|---|---|---|---|---|---|
| Early . | Late . | Early . | Late . | Early . | Late . | |
| LPS | ++ | +++ | R | R | R | R |
| Poly (I:C) | ++ | + | + | +++ | + | +++ |
| CpG | ++ | +++ | R | R | +++ | + |
Degree of GC sensitivity: high (+++), moderate (++), low (+), GR resistant (R).
MAPK indicates mitogen-activated protein kinase; JNK, Janus kinase; ERK, extracellular signal-related kinase; LPS, lipopolysaccharide; and GC, glucocorticoid.