NFAT promoter binding sites and direct transcriptional partners important for CD4+ T helper effector functions
| Gene promoter . | NFAT interaction partner . | Positive/negative* . | Reference(s) . |
|---|---|---|---|
| Th0 | |||
| Il2 | AP-1 (Fos/Jun) | + | 4,12,19 |
| ICER | − | 20 | |
| p21SNFT/Jun | − | 21 | |
| Foxp3/Runx1 | − | 22,23 | |
| PPAR-γ (NR1C3) | − | 24 | |
| NFAT2 | AP-1 | + | 22 |
| Foxp3 | − | 22 | |
| Cd25 | AP-1 | + | 19,25 |
| Gitr | − | 26 | |
| Il4 | Mina | − | 27 |
| Th1 | |||
| Tbx21 (T-bet) | + | 28 | |
| Ifng | AP-1 | + | 29 |
| T-bet | + | 30 | |
| Twist | + | 31 | |
| IL-12Rβ2 | − | 29 | |
| Th2 | |||
| Il4 | AP-1 | + | 19 |
| c-MAF/IRF4 | + | 32,33 | |
| Runx1 | − | 34,35 | |
| PPAR-γ (NR1C3) | − | 36 | |
| BRG1 | + | 37 | |
| GATA3 | + | 16,30 | |
| Il5 | + | 19 | |
| Il13 | + | 19 | |
| Il10 | IRF4 | + | 38 |
| Th17 | |||
| RORγt | AP-1 | + | 39,40 |
| Foxp3 | − | 41 | |
| IRF4 | + | 39,42 | |
| IL17 | AP-1 | + | 43,44 |
| Runx1 | + | 45 | |
| IL21 | + | 46,47 | |
| Il22 | + | 40 | |
| IL10 | + | 38 | |
| IL6 | + | 6,40,48 | |
| iTreg | |||
| Foxp3 | + | 4,23,49,50 | |
| Smad3 | + | 49,50 | |
| AP-1 | + | 49 | |
| Runx1 | + | 49 | |
| Gitr | Foxp3/Runx1 | + | 23 |
| Cd25 | Foxp3/Runx1 | + | 23,51 |
| Ctla4 | Foxp3/Runx1 | + | 23,51 |
| Gene promoter . | NFAT interaction partner . | Positive/negative* . | Reference(s) . |
|---|---|---|---|
| Th0 | |||
| Il2 | AP-1 (Fos/Jun) | + | 4,12,19 |
| ICER | − | 20 | |
| p21SNFT/Jun | − | 21 | |
| Foxp3/Runx1 | − | 22,23 | |
| PPAR-γ (NR1C3) | − | 24 | |
| NFAT2 | AP-1 | + | 22 |
| Foxp3 | − | 22 | |
| Cd25 | AP-1 | + | 19,25 |
| Gitr | − | 26 | |
| Il4 | Mina | − | 27 |
| Th1 | |||
| Tbx21 (T-bet) | + | 28 | |
| Ifng | AP-1 | + | 29 |
| T-bet | + | 30 | |
| Twist | + | 31 | |
| IL-12Rβ2 | − | 29 | |
| Th2 | |||
| Il4 | AP-1 | + | 19 |
| c-MAF/IRF4 | + | 32,33 | |
| Runx1 | − | 34,35 | |
| PPAR-γ (NR1C3) | − | 36 | |
| BRG1 | + | 37 | |
| GATA3 | + | 16,30 | |
| Il5 | + | 19 | |
| Il13 | + | 19 | |
| Il10 | IRF4 | + | 38 |
| Th17 | |||
| RORγt | AP-1 | + | 39,40 |
| Foxp3 | − | 41 | |
| IRF4 | + | 39,42 | |
| IL17 | AP-1 | + | 43,44 |
| Runx1 | + | 45 | |
| IL21 | + | 46,47 | |
| Il22 | + | 40 | |
| IL10 | + | 38 | |
| IL6 | + | 6,40,48 | |
| iTreg | |||
| Foxp3 | + | 4,23,49,50 | |
| Smad3 | + | 49,50 | |
| AP-1 | + | 49 | |
| Runx1 | + | 49 | |
| Gitr | Foxp3/Runx1 | + | 23 |
| Cd25 | Foxp3/Runx1 | + | 23,51 |
| Ctla4 | Foxp3/Runx1 | + | 23,51 |
Activating or inhibitory effect of NFAT binding in the given promoter context.