Absolute thymocyte numbers in the steady state in wild-type, CCR7−/−, CCR9−/−, and DKO mice
| . | wt . | CCR7−/− . | CCR9−/− . | DKO . |
|---|---|---|---|---|
| Total | 2.0 ± 0.10 × 108 | 1.2 ± 0.14 × 108 | 2.3 ± 0.05 × 108 | 2.1 ± 0.5 × 108 |
| DN | 6.2 ± 0.40 × 106 | 3.0 ± 0.37 × 106 | 6.3 ± 1.0 × 106 | 3.7 ± 1 × 106 |
| ETP | 2.2 ± 0.18 × 104 | 3.2 ± 0.49 × 104 | 0.36 ± 0.24 × 104 | 0.018 ± 0.009 × 104 |
| DN2 | 2.5 ± 0.20 × 104 | 3.0 ± 0.43 × 104 | 0.26 ± 0.09 × 104 | 0.047 ± 0.021 × 104 |
| DN3 | 2.7 ± 0.18 × 106 | 1.3 ± 0.18 × 106 | 1.7 ± 0.38 × 106 | 1.1 ± 0.3 × 106 |
| DP | 1.7 ± 0.09 × 108 | 1.0 ± 0.12 × 108 | 2.1 ± 0.07 × 108 | 2.0 ± 0.51 × 108 |
| CD4 SP | 1.8 ± 0.11 × 107 | 1.1 ± 0.14 × 107 | 1.3 ± 0.26 × 107 | 1.1 ± 0.29 × 107 |
| CD8 SP | 7.4 ± 0.50 × 106 | 4.0 ± 0.47 × 106 | 4.8 ± 1.5 × 106 | 4.5 ± 1.2 × 106 |
| . | wt . | CCR7−/− . | CCR9−/− . | DKO . |
|---|---|---|---|---|
| Total | 2.0 ± 0.10 × 108 | 1.2 ± 0.14 × 108 | 2.3 ± 0.05 × 108 | 2.1 ± 0.5 × 108 |
| DN | 6.2 ± 0.40 × 106 | 3.0 ± 0.37 × 106 | 6.3 ± 1.0 × 106 | 3.7 ± 1 × 106 |
| ETP | 2.2 ± 0.18 × 104 | 3.2 ± 0.49 × 104 | 0.36 ± 0.24 × 104 | 0.018 ± 0.009 × 104 |
| DN2 | 2.5 ± 0.20 × 104 | 3.0 ± 0.43 × 104 | 0.26 ± 0.09 × 104 | 0.047 ± 0.021 × 104 |
| DN3 | 2.7 ± 0.18 × 106 | 1.3 ± 0.18 × 106 | 1.7 ± 0.38 × 106 | 1.1 ± 0.3 × 106 |
| DP | 1.7 ± 0.09 × 108 | 1.0 ± 0.12 × 108 | 2.1 ± 0.07 × 108 | 2.0 ± 0.51 × 108 |
| CD4 SP | 1.8 ± 0.11 × 107 | 1.1 ± 0.14 × 107 | 1.3 ± 0.26 × 107 | 1.1 ± 0.29 × 107 |
| CD8 SP | 7.4 ± 0.50 × 106 | 4.0 ± 0.47 × 106 | 4.8 ± 1.5 × 106 | 4.5 ± 1.2 × 106 |
Thymocyte numbers are presented as ± SEM.
wt indicates wild type; DN, double negative; ETP, early T lineage progenitor; DP, double positive; and SP, single positive.