Immunologic characteristics of the different transgenic mouse strains
| Strain . | Specifity . | Deficiency . | Genetic background . |
|---|---|---|---|
| 2C/RAG2 | TCR-transgenic mouse, specificity for SIYRYYG, a neoantigen, MHC I–restricted | Mature T and B cells other than specific TCR | C57Bl/6 (> 10 generations) |
| OTI/RAG1 | TCR-transgenic mouse, specificity for a peptide from ovalbumin, SIINFEKL, MHC I–restricted | Mature T and B cells other than specific TCR | 129/SJ (> 10 generations) |
| OTII/RAG1 | TCR-transgenic mouse, specificity for a peptide from ovalbumin, SIINFEKL, MHC II–restricted | Mature T and B cells other than specific TCR | C57Bl/6 (> 10 generations) |
| 2D2/RAG1 | TCR-transgenic mouse, specificity for a peptide from myelin-oligodendrocyte protein (MOG35–55), MHC II–restricted | Mature T and B cells other than specific TCR | C57Bl/6 (> 10 generations) |
| CD28−/− | — | Costimulatory TCR CD28 | C57Bl/6 (> 10 generations) |
| B7-H1−/− | — | Coinhibitory TCR ligand B7-H1 (CD274) | C57Bl/6 (> 10 generations) |
| PD1−/− | — | Coinhibitory TCR PD1 | C57Bl/6 (> 10 generations) |
| CD1d−/− | — | NKT cells | C57Bl/6 (> 10 generations) |
| γΔ−/− | — | γΔ T cells | C57Bl/6 (> 10 generations) |
| Strain . | Specifity . | Deficiency . | Genetic background . |
|---|---|---|---|
| 2C/RAG2 | TCR-transgenic mouse, specificity for SIYRYYG, a neoantigen, MHC I–restricted | Mature T and B cells other than specific TCR | C57Bl/6 (> 10 generations) |
| OTI/RAG1 | TCR-transgenic mouse, specificity for a peptide from ovalbumin, SIINFEKL, MHC I–restricted | Mature T and B cells other than specific TCR | 129/SJ (> 10 generations) |
| OTII/RAG1 | TCR-transgenic mouse, specificity for a peptide from ovalbumin, SIINFEKL, MHC II–restricted | Mature T and B cells other than specific TCR | C57Bl/6 (> 10 generations) |
| 2D2/RAG1 | TCR-transgenic mouse, specificity for a peptide from myelin-oligodendrocyte protein (MOG35–55), MHC II–restricted | Mature T and B cells other than specific TCR | C57Bl/6 (> 10 generations) |
| CD28−/− | — | Costimulatory TCR CD28 | C57Bl/6 (> 10 generations) |
| B7-H1−/− | — | Coinhibitory TCR ligand B7-H1 (CD274) | C57Bl/6 (> 10 generations) |
| PD1−/− | — | Coinhibitory TCR PD1 | C57Bl/6 (> 10 generations) |
| CD1d−/− | — | NKT cells | C57Bl/6 (> 10 generations) |
| γΔ−/− | — | γΔ T cells | C57Bl/6 (> 10 generations) |
— indicates not applicable.