Association of rising antibody titers against ALK with clinical features of the ALCL patients
| Category . | No. of patients (%) . | ALK antibody titer patients, no. (%) . | P . | ||
|---|---|---|---|---|---|
| 0-≤ 1/750 . | 1/2025-< 1/20 250 . | ≥ 1/60 750 . | |||
| All patients | 95 | 27 | 39 | 29 | |
| Age, y | .50 | ||||
| Less than 1 | 1 (1) | 1 (4) | |||
| 1-9 | 33 (35) | 10 (37) | 15 (39) | 8 (28) | |
| 10-18 | 61 (64) | 16 (59) | 24 (61) | 21 (72) | |
| Sex | .02 | ||||
| Female | 35 (37) | 7 (26) | 11 (28) | 17 (41) | |
| Male | 60 (63) | 20 (74) | 28 (72) | 12 (59) | |
| Skin | .22 | ||||
| No | 74 (78) | 18 (67) | 31 (80) | 25 (86) | |
| Yes | 21 (22) | 9 (33) | 8 (20) | 4 (14) | |
| Mediastinum | .01 | ||||
| No | 44 (46) | 8 (30) | 16 (41) | 20 (69) | |
| Yes | 51 (54) | 19 (70) | 23 (59) | 9 (31) | |
| Visceral organs* | .01 | ||||
| No | 62 (65) | 16 (59) | 21 (54) | 25 (86) | |
| Yes | 33 (35) | 11 (41) | 18 (46) | 4 (14) | |
| CNS | .32 | ||||
| No | 90 (95) | 25 (93) | 36 (92) | 29 (100) | |
| Yes | 5 (5) | 2 (7) | 3 (8) | ||
| BM | .11 | ||||
| Negative | 81 (85) | 22 (82) | 31 (80) | 28 (97) | |
| Positive | 14 (15) | 5 (19) | 8 (20) | 1 (3) | |
| Stage† | .004 | ||||
| I | 9 (9) | 2 (7) | 7 (24) | ||
| II | 14 (15) | 2 (7) | 6 (15) | 6 (21) | |
| III | 54 (57) | 17 (63) | 22 (57) | 15 (52) | |
| IV | 18 (19) | 6 (22) | 11 (28) | 1 (3) | |
| Histologic subtype | .15 | ||||
| Common type | 47 (49) | 12 (44) | 17 (44) | 18 (62) | |
| Small cell, lymphohistiocytic, mixed, giant, not further classified | 42 (44) | 14 (52) | 20 (51) | 8 (28) | |
| NA | 6 (6) | 1 (4) | 2 (5) | 3 (10) | |
| Category . | No. of patients (%) . | ALK antibody titer patients, no. (%) . | P . | ||
|---|---|---|---|---|---|
| 0-≤ 1/750 . | 1/2025-< 1/20 250 . | ≥ 1/60 750 . | |||
| All patients | 95 | 27 | 39 | 29 | |
| Age, y | .50 | ||||
| Less than 1 | 1 (1) | 1 (4) | |||
| 1-9 | 33 (35) | 10 (37) | 15 (39) | 8 (28) | |
| 10-18 | 61 (64) | 16 (59) | 24 (61) | 21 (72) | |
| Sex | .02 | ||||
| Female | 35 (37) | 7 (26) | 11 (28) | 17 (41) | |
| Male | 60 (63) | 20 (74) | 28 (72) | 12 (59) | |
| Skin | .22 | ||||
| No | 74 (78) | 18 (67) | 31 (80) | 25 (86) | |
| Yes | 21 (22) | 9 (33) | 8 (20) | 4 (14) | |
| Mediastinum | .01 | ||||
| No | 44 (46) | 8 (30) | 16 (41) | 20 (69) | |
| Yes | 51 (54) | 19 (70) | 23 (59) | 9 (31) | |
| Visceral organs* | .01 | ||||
| No | 62 (65) | 16 (59) | 21 (54) | 25 (86) | |
| Yes | 33 (35) | 11 (41) | 18 (46) | 4 (14) | |
| CNS | .32 | ||||
| No | 90 (95) | 25 (93) | 36 (92) | 29 (100) | |
| Yes | 5 (5) | 2 (7) | 3 (8) | ||
| BM | .11 | ||||
| Negative | 81 (85) | 22 (82) | 31 (80) | 28 (97) | |
| Positive | 14 (15) | 5 (19) | 8 (20) | 1 (3) | |
| Stage† | .004 | ||||
| I | 9 (9) | 2 (7) | 7 (24) | ||
| II | 14 (15) | 2 (7) | 6 (15) | 6 (21) | |
| III | 54 (57) | 17 (63) | 22 (57) | 15 (52) | |
| IV | 18 (19) | 6 (22) | 11 (28) | 1 (3) | |
| Histologic subtype | .15 | ||||
| Common type | 47 (49) | 12 (44) | 17 (44) | 18 (62) | |
| Small cell, lymphohistiocytic, mixed, giant, not further classified | 42 (44) | 14 (52) | 20 (51) | 8 (28) | |
| NA | 6 (6) | 1 (4) | 2 (5) | 3 (10) | |