Effect of wiskostatin on chemokine-induced LFA-1 high-affinity state
| Stimulation . | Time, min . | Vehicle . | Wiskostatin . | ||
|---|---|---|---|---|---|
| Mean . | Mean ratio . | Mean . | Mean ratio . | ||
| Control | 8.4 | 13.0 | |||
| CXCL12 (10nM) | 3 | 100.8 | 12.0 | 42.2 | 3.2 |
| CXCL12 (1nM) | 75.3 | 9.0 | 30.5 | 2.3 | |
| CXCL12 (10nM) | 7 | 108.5 | 12.9 | 39.6 | 3.0 |
| CXCL12 (1nM) | 113.2 | 13.5 | 51.4 | 3.9 | |
| CX3CL1 (10nM) | 3 | 36.5 | 4.3 | 22.1 | 1.7 |
| CX3CL1 (1nM) | 45.7 | 5.4 | 17.6 | 1.3 | |
| CX3CL1 (10nM) | 7 | 33.4 | 4.0 | 34.5 | 2.6 |
| CX3CL1 (1nM) | 60.4 | 7.2 | 23.7 | 1.8 | |
| Stimulation . | Time, min . | Vehicle . | Wiskostatin . | ||
|---|---|---|---|---|---|
| Mean . | Mean ratio . | Mean . | Mean ratio . | ||
| Control | 8.4 | 13.0 | |||
| CXCL12 (10nM) | 3 | 100.8 | 12.0 | 42.2 | 3.2 |
| CXCL12 (1nM) | 75.3 | 9.0 | 30.5 | 2.3 | |
| CXCL12 (10nM) | 7 | 108.5 | 12.9 | 39.6 | 3.0 |
| CXCL12 (1nM) | 113.2 | 13.5 | 51.4 | 3.9 | |
| CX3CL1 (10nM) | 3 | 36.5 | 4.3 | 22.1 | 1.7 |
| CX3CL1 (1nM) | 45.7 | 5.4 | 17.6 | 1.3 | |
| CX3CL1 (10nM) | 7 | 33.4 | 4.0 | 34.5 | 2.6 |
| CX3CL1 (1nM) | 60.4 | 7.2 | 23.7 | 1.8 | |