Parasitologic and hematologic parameters at recruitment (3 months of age)
| . | HbAA (n = 773)* . | HbAC (n = 106) . | HbCC (n = 2) . | HbAS (n = 110) . | HbCS (n = 12) . | HbSS (n = 6) . | Total (n = 1009)* . |
|---|---|---|---|---|---|---|---|
| Positive parasitemia, n (%) | 120 (15.5) | 17 (16.0) | 0 (0.0) | 9 (8.2)† | 1 (8.3) | 1 (16.7) | 148 (14.7) |
| Asymptomatic parasitemia, n (%) | 103 (13.3) | 15 (14.2) | 0 (0.0) | 8 (8.3)‡ | 1 (8.3) | 1 (16.7) | 128 (12.7) |
| Parasitemia, geomean (95%CI) | 853 (619-1177) | 566 (209-1530) | — | 312 (70-1382)§ | 760 | 80 | 753 (561-1010) |
| Parasitemia in asymptomatic children, geomean (95%CI) | 709 (503-999) | 446 (160-1248) | — | 257 (49-1337) | — | — | 620 (454-847) |
| Malaria, % | 15 (1.9) | 2 (1.9) | 0 (0.0) | 1 (0.9) | 0 (0.0) | 0 (0.0) | 18 (1.8) |
| Anemia, %‖ | 12 (1.6) | 3 (2.8) | 1 (50.0) | 0 (0.0) | 4 (33.3) | 2 (33.3) | 22 (2.2) |
| Hemoglobin, g/dL, median (quartiles) | 10.4 (9.5-11.2) | 10.0 (9.2-11.0)¶ | 8.7 (7.4-10.0) | 10.5 (9.7-11.2) | 9.1 (7.4-9.9)# | 9.2 (7.4-10.0)** | 10.4 (9.5-11.2) |
| . | HbAA (n = 773)* . | HbAC (n = 106) . | HbCC (n = 2) . | HbAS (n = 110) . | HbCS (n = 12) . | HbSS (n = 6) . | Total (n = 1009)* . |
|---|---|---|---|---|---|---|---|
| Positive parasitemia, n (%) | 120 (15.5) | 17 (16.0) | 0 (0.0) | 9 (8.2)† | 1 (8.3) | 1 (16.7) | 148 (14.7) |
| Asymptomatic parasitemia, n (%) | 103 (13.3) | 15 (14.2) | 0 (0.0) | 8 (8.3)‡ | 1 (8.3) | 1 (16.7) | 128 (12.7) |
| Parasitemia, geomean (95%CI) | 853 (619-1177) | 566 (209-1530) | — | 312 (70-1382)§ | 760 | 80 | 753 (561-1010) |
| Parasitemia in asymptomatic children, geomean (95%CI) | 709 (503-999) | 446 (160-1248) | — | 257 (49-1337) | — | — | 620 (454-847) |
| Malaria, % | 15 (1.9) | 2 (1.9) | 0 (0.0) | 1 (0.9) | 0 (0.0) | 0 (0.0) | 18 (1.8) |
| Anemia, %‖ | 12 (1.6) | 3 (2.8) | 1 (50.0) | 0 (0.0) | 4 (33.3) | 2 (33.3) | 22 (2.2) |
| Hemoglobin, g/dL, median (quartiles) | 10.4 (9.5-11.2) | 10.0 (9.2-11.0)¶ | 8.7 (7.4-10.0) | 10.5 (9.7-11.2) | 9.1 (7.4-9.9)# | 9.2 (7.4-10.0)** | 10.4 (9.5-11.2) |
— indicates not applicable.
One sample was missing at recruitment visit. Two children with parasitemia < 500 parasites/μL and fever.
HbAS versus HbAA (OR = 0.48; 95% CI, 0.21-0.99, P = .041).
HbAS versus HbAA (OR = 0.51; 95% CI, 0.21-1.09, P = .073).
HbAS versus HbAA (Wilcoxon test, P < .05).
Hemoglobin less than 7.5 g/dL.
HbAC versus HbAA (Wilcoxon test, P < .02).
HbCS versus HbAA (Wilcoxon test, P < .001).
HbSS versus HbAA (Wilcoxon test, P < .05).