Clonal analysis of individual erythroid colonies and purified leukemic blasts from 4 patients progressing to JAK2 wild-type leukemia
| Patient . | Additional mutation . | Erythroid colonies . | JAK2 wild-type leukemic blasts . | |
|---|---|---|---|---|
| JAK2 mutant . | JAK2 wild-type . | |||
| 8 | del(20q) | + | − | − |
| 8 | TET2 | − | + | + |
| 8 | RUNX1 | − | − | + |
| 9 | CBL | − | − | + |
| 12 | TP53 | − | − | + |
| 15 | add(9) | + | − | − |
| 15 | TET2 | − | − | + |
| Patient . | Additional mutation . | Erythroid colonies . | JAK2 wild-type leukemic blasts . | |
|---|---|---|---|---|
| JAK2 mutant . | JAK2 wild-type . | |||
| 8 | del(20q) | + | − | − |
| 8 | TET2 | − | + | + |
| 8 | RUNX1 | − | − | + |
| 9 | CBL | − | − | + |
| 12 | TP53 | − | − | + |
| 15 | add(9) | + | − | − |
| 15 | TET2 | − | − | + |
+ Indicates present; and −, absent.