Results of the multivariate analysis of factors affecting outcome of HLA-matched allo-HSCT for adults with AML in first complete remission
| Factor . | LFS . | RI . | NRM . | |||
|---|---|---|---|---|---|---|
| HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . | |
| Donor type (URD vs sibling) | 0.62 (0.53-0.74) | < .001 | 1.61 (1.28-2.04) | < .001 | 1.59 (1.23-2.04) | < .001 |
| Conditioning (TBI vs Cht) | 1.2 (1.03-1.4) | .02 | 0.74 (0.6-0.9) | .003 | 0.96 (0.77-1.2) | .76 |
| Year of HSCT (2003 or earlier vs later than 2003) | 1.13 (0.96-1.33) | .14 | 0.98 (0.78-1.22) | .87 | 0.79 (0.62-1) | .05 |
| Patient age (≥ 40 vs < 40 y) | 0.75 (0.64-0.87) | < .001 | 1.1 (0.89-1.33) | .38 | 1.72 (1.37-2.17) | < .001 |
| Interval of diagnosis HSCT (≥ 5 vs < 5 mo) | 1.04 (0.89-1.21) | .66 | 0.8 (0.65-0.98) | .035 | 1.2 (0.96-1.52) | .11 |
| Source of stem cells (PB vs BM) | 0.83 (0.7-0.97) | .02 | 1.3 (1.04-1.64) | .02 | 1.1 (0.86-1.39) | .44 |
| HDI (> 0.9382 vs ≤ 0.9382) | 1.36 (1.08-1.71) | .008 | 0.72 (0.53-0.99) | .04 | 0.76 (0.54-1.05) | .1 |
| GDPI (> 0.9382 vs ≤ 0.9382) | 1.15 (0.98-1.35) | .09 | 0.85 (0.69-1.06) | .16 | 0.88 (0.7-1.14) | .34 |
| Factor . | LFS . | RI . | NRM . | |||
|---|---|---|---|---|---|---|
| HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . | |
| Donor type (URD vs sibling) | 0.62 (0.53-0.74) | < .001 | 1.61 (1.28-2.04) | < .001 | 1.59 (1.23-2.04) | < .001 |
| Conditioning (TBI vs Cht) | 1.2 (1.03-1.4) | .02 | 0.74 (0.6-0.9) | .003 | 0.96 (0.77-1.2) | .76 |
| Year of HSCT (2003 or earlier vs later than 2003) | 1.13 (0.96-1.33) | .14 | 0.98 (0.78-1.22) | .87 | 0.79 (0.62-1) | .05 |
| Patient age (≥ 40 vs < 40 y) | 0.75 (0.64-0.87) | < .001 | 1.1 (0.89-1.33) | .38 | 1.72 (1.37-2.17) | < .001 |
| Interval of diagnosis HSCT (≥ 5 vs < 5 mo) | 1.04 (0.89-1.21) | .66 | 0.8 (0.65-0.98) | .035 | 1.2 (0.96-1.52) | .11 |
| Source of stem cells (PB vs BM) | 0.83 (0.7-0.97) | .02 | 1.3 (1.04-1.64) | .02 | 1.1 (0.86-1.39) | .44 |
| HDI (> 0.9382 vs ≤ 0.9382) | 1.36 (1.08-1.71) | .008 | 0.72 (0.53-0.99) | .04 | 0.76 (0.54-1.05) | .1 |
| GDPI (> 0.9382 vs ≤ 0.9382) | 1.15 (0.98-1.35) | .09 | 0.85 (0.69-1.06) | .16 | 0.88 (0.7-1.14) | .34 |
HDI and GDPI were analyzed separately because of internal correlation. Values for other prognostic factors are presented for the models, including HDI. The entire models, including GDPI, have not been shown.
HR indicates hazard ratio; CI, confidence interval; URD, unrelated donor; TBI, total body irradiation; Cht, chemotherapy-based conditioning; HSCT, hematopoietic stem cell transplantation; PB, peripheral blood; and BM, bone marrow.