Nf1 insertions and Ras pathway muations in CALM-AF10 mice with Zeb2 insertions
| ID . | Diagnosis . | IgH rearrangement . | Proviral insertion . | Gene mutation . |
|---|---|---|---|---|
| 5 | B-ALL | Yes | — | Ptpn11 |
| 17 | B-ALL | Yes | Nf1 | — |
| 21 | B-ALL | Yes | — | — |
| 23 | B-ALL | Yes | Nf1 | — |
| 25 | B-ALL | Yes | Nf1 | Kras |
| 26 | B-ALL | Yes | Nf1 | — |
| 27 | B-ALL | Yes | — | Kras |
| 36 | AML | No | Nf1 | — |
| 51 | Biphenotypic | Yes | — | — |
| 80 | Biphenotypic | Yes | — | — |
| 98 | B-ALL | Yes | Nf1 | — |
| ID . | Diagnosis . | IgH rearrangement . | Proviral insertion . | Gene mutation . |
|---|---|---|---|---|
| 5 | B-ALL | Yes | — | Ptpn11 |
| 17 | B-ALL | Yes | Nf1 | — |
| 21 | B-ALL | Yes | — | — |
| 23 | B-ALL | Yes | Nf1 | — |
| 25 | B-ALL | Yes | Nf1 | Kras |
| 26 | B-ALL | Yes | Nf1 | — |
| 27 | B-ALL | Yes | — | Kras |
| 36 | AML | No | Nf1 | — |
| 51 | Biphenotypic | Yes | — | — |
| 80 | Biphenotypic | Yes | — | — |
| 98 | B-ALL | Yes | Nf1 | — |
Eight of 11 mice with Zeb2 insertions also had Nf1 insertions and/or Ras pathway activating point mutations. Only 6 of 31 mice without Zeb2 insertions have Nf1 insertions, and none of these mice had Ras pathway activating point mutations (P < .003).
— indicates no Nf1 insertion or gene mutation was identified.