Age-adjusted ORs for disease-specific admission by HbS genotype
| Case category . | HbAA . | HbAS . | P . | SCA . | P . |
|---|---|---|---|---|---|
| Uncomplicated malaria | 1 | 0.24 (0.17-0.36) | < .001 | 0.43 (0.09-2.10) | .30 |
| Severe malaria | 1 | 0.12 (0.08-0.18) | < .001 | 0.80 (0.25-2.51) | .70 |
| Nonmalaria illnesses | 1 | 0.78 (0.60-1.01) | .066 | 4.17 (1.95-8.92) | < .001 |
| Bacteremia | 1 | 0.60 (0.48-0.76) | < .001 | 8.73 (4.51-16.89) | < .001 |
| Case category . | HbAA . | HbAS . | P . | SCA . | P . |
|---|---|---|---|---|---|
| Uncomplicated malaria | 1 | 0.24 (0.17-0.36) | < .001 | 0.43 (0.09-2.10) | .30 |
| Severe malaria | 1 | 0.12 (0.08-0.18) | < .001 | 0.80 (0.25-2.51) | .70 |
| Nonmalaria illnesses | 1 | 0.78 (0.60-1.01) | .066 | 4.17 (1.95-8.92) | < .001 |
| Bacteremia | 1 | 0.60 (0.48-0.76) | < .001 | 8.73 (4.51-16.89) | < .001 |
Values are ORs (95% CI) compared with the reference group (HbAA) adjusted for age group (0-23 months, 24-59 months) by logistic regression. Case categories are as defined in “Study participants.” In a subanalysis restricted to bacteremia caused by the rapidly progressive condition Streptococcus pneumoniae, the OR for SCA in cases versus controls was 15.3 (95% CI, 7.3-35.1; P < .001).