Table 2

Hemodynamic parameters of SCD mice treated in protocol 2

TreatmentsMice, nWeight, g*Venules, nVenular diameter, μ*Centerline velocity, mm/s*WBC count (103/μL)*
PBS 11 25.5 ± 0.4 132 19.8 ± 0.1 1.2 ± 0.1 12.1 ± 1.9 
GMI-1070 27.0 ± 0.9 130 19.9 ± 0.2 2.5 ± 0.2 18.6 ± 4.5 
TreatmentsMice, nWeight, g*Venules, nVenular diameter, μ*Centerline velocity, mm/s*WBC count (103/μL)*
PBS 11 25.5 ± 0.4 132 19.8 ± 0.1 1.2 ± 0.1 12.1 ± 1.9 
GMI-1070 27.0 ± 0.9 130 19.9 ± 0.2 2.5 ± 0.2 18.6 ± 4.5 

SCD indicates sickle cell disease; WBC, white blood cell; and PBS, phosphate-buffered saline.

*

Data are presented as mean ± SEM.

P < .001 compared with PBS.

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