Clinical characteristics of the 143 patients entering the study*
| . | Age > 60 y (n = 40) . | Age < 60 y (n = 103) . | Total (n = 143) . | P . |
|---|---|---|---|---|
| Sex | ||||
| Male | 21 | 59 | 80 | NS |
| Female | 19 | 44 | 63 | |
| WBC | ||||
| Less than 50 × 109/L | 37 | 73 | 110 | NS |
| 50-100 × 109/L | 1 | 21 | 22 | |
| More than 100 × 109/L | 2 | 9 | 11 | |
| FAB | ||||
| M0 | 2 | 11 | 13 | NS |
| M1 | 9 | 21 | 30 | |
| M2 | 13 | 31 | 44 | |
| M4 | 9 | 13 | 22 | |
| M5 | 5 | 26 | 31 | |
| M6 | 2 | 1 | 3 | |
| FLT3 status (n = 129) | ||||
| Wild-type | 31 | 79 | 110 | NS |
| ITD | 5 | 14 | 19 | |
| NPM1 status (n = 135) | ||||
| Wild-type | 27 | 68 | 95 | NS |
| Mutated | 13 | 27 | 40 | |
| Cytogenetics | .014 | |||
| Good-risk | 2 | 20 | 22 | |
| Intermediate-risk | 8 | 24 | 32 | |
| Normal karyotype | 26 | 57 | 83 | |
| Poor-risk | 4 | 2 | 6 |
| . | Age > 60 y (n = 40) . | Age < 60 y (n = 103) . | Total (n = 143) . | P . |
|---|---|---|---|---|
| Sex | ||||
| Male | 21 | 59 | 80 | NS |
| Female | 19 | 44 | 63 | |
| WBC | ||||
| Less than 50 × 109/L | 37 | 73 | 110 | NS |
| 50-100 × 109/L | 1 | 21 | 22 | |
| More than 100 × 109/L | 2 | 9 | 11 | |
| FAB | ||||
| M0 | 2 | 11 | 13 | NS |
| M1 | 9 | 21 | 30 | |
| M2 | 13 | 31 | 44 | |
| M4 | 9 | 13 | 22 | |
| M5 | 5 | 26 | 31 | |
| M6 | 2 | 1 | 3 | |
| FLT3 status (n = 129) | ||||
| Wild-type | 31 | 79 | 110 | NS |
| ITD | 5 | 14 | 19 | |
| NPM1 status (n = 135) | ||||
| Wild-type | 27 | 68 | 95 | NS |
| Mutated | 13 | 27 | 40 | |
| Cytogenetics | .014 | |||
| Good-risk | 2 | 20 | 22 | |
| Intermediate-risk | 8 | 24 | 32 | |
| Normal karyotype | 26 | 57 | 83 | |
| Poor-risk | 4 | 2 | 6 |
Patients were stratified according to refined MRC classification of cytogenetic risk, as follows: “favorable” risk, cases with t(8;21), t(15;17), or inv(16)/t(16;16); “adverse” risk, cases with complex cytogenetic changes (> 3 unrelated abnormalities), −5, add(5q)/del(5q), −7/add(7q), t(6;11), t(10;11), t(9;22), −17, abn(17p) with other changes, 3q abnormalities excluding t(3;5), inv(3)/t(3;3); and “intermediate” risk, cases with normal karyotype and other noncomplex.
WBC indicates white blood cell; FAB, French-American-British; and NS, not significant.