The cause of death of pediatric patients with favorable alterations
| RNA no. . | Alterations . | Mutations . | Sex . | Age, y . | WBC, 109/L . | FAB . | Chromosome . | Risks . | Relapse . | Cause of death . |
|---|---|---|---|---|---|---|---|---|---|---|
| 13 | RUNX1-RUNX1T1 | KIT | M | 15.7 | 29.2 | M2 | 46,XY,t(8;21)(q22;q22) [20] | Low | + | Acute GVHD grade |
| 31 | RUNX1-RUNX1T1 | — | M | 17.9 | 6.9 | M2 | 45,X,-Y,t(8;21)(q22;q22)[18]/46,XY[2] | Low | + | Dyspnea due to GVHD and TMA |
| 134 | RUNX1-RUNX1T1 | KIT | F | 3.6 | 11.7 | M2 | 46,XX,t(8;21)(q22;q22)[12]/46,XX[8] | Low | + | Infection, cardiac failure |
| 146 | RUNX1-RUNX1T1 | — | M | 5.4 | 9.8 | RAEB-T | 45,X,-Y,t(8;21)(q22;q22)[20] | Low | + | Primary disease |
| 172 | RUNX1-RUNX1T1 | — | M | 7.8 | 9.3 | RAEB-T | 45,X,-Y,t(8;21)(q22;q22)[19]/46,XY[1] | Low | + | Primary disease |
| 200 | RUNX1-RUNX1T1 | KIT | F | 6.1 | 18.7 | M2 | 46,XX,t(8;14;21)(q22;q24;q22)[20] | Low | + | Primary disease |
| 355 | RUNX1-RUNX1T1 | - | M | 14.5 | 19.2 | RAEB-T | 46,XY,t(8;18;21)(q22;q21;q22)[12]/46,XY[2] | Low | + | Sepsis |
| 383 | RUNX1-RUNX1T1 | KIT, RUNX1 | M | 9.9 | 38.7 | M2 | 46,XY,t(8;19)(q22;p13) or t(8;19;21)(q22;p13;q22)[20] | Non-CR | − | Primary disease |
| 209 | CBFB-MYH11 | FLT3-ITD | M | 16.2 | 172.2 | M4Eo | 48,XY,+6,+8,inv(16)(p13q22)[8]/49, sl,+21[5]/ 50, sl1,+10[5]/49, sl2, +8[2]/49, sl3,+11[2] | Induction death | − | Intracranial hemorrhage (day 16) |
| 26 | biallelic CEBPA | — | M | 6.8 | 10.7 | M1 | 46,XY[20] | Intermediate | − | ARDS |
| 97 | NPM1 | — | F | 11.6 | 38.2 | RAEB-T | 47,XX,+18[1]/46,XX[19] | Intermediate | + | Primary disease |
| RNA no. . | Alterations . | Mutations . | Sex . | Age, y . | WBC, 109/L . | FAB . | Chromosome . | Risks . | Relapse . | Cause of death . |
|---|---|---|---|---|---|---|---|---|---|---|
| 13 | RUNX1-RUNX1T1 | KIT | M | 15.7 | 29.2 | M2 | 46,XY,t(8;21)(q22;q22) [20] | Low | + | Acute GVHD grade |
| 31 | RUNX1-RUNX1T1 | — | M | 17.9 | 6.9 | M2 | 45,X,-Y,t(8;21)(q22;q22)[18]/46,XY[2] | Low | + | Dyspnea due to GVHD and TMA |
| 134 | RUNX1-RUNX1T1 | KIT | F | 3.6 | 11.7 | M2 | 46,XX,t(8;21)(q22;q22)[12]/46,XX[8] | Low | + | Infection, cardiac failure |
| 146 | RUNX1-RUNX1T1 | — | M | 5.4 | 9.8 | RAEB-T | 45,X,-Y,t(8;21)(q22;q22)[20] | Low | + | Primary disease |
| 172 | RUNX1-RUNX1T1 | — | M | 7.8 | 9.3 | RAEB-T | 45,X,-Y,t(8;21)(q22;q22)[19]/46,XY[1] | Low | + | Primary disease |
| 200 | RUNX1-RUNX1T1 | KIT | F | 6.1 | 18.7 | M2 | 46,XX,t(8;14;21)(q22;q24;q22)[20] | Low | + | Primary disease |
| 355 | RUNX1-RUNX1T1 | - | M | 14.5 | 19.2 | RAEB-T | 46,XY,t(8;18;21)(q22;q21;q22)[12]/46,XY[2] | Low | + | Sepsis |
| 383 | RUNX1-RUNX1T1 | KIT, RUNX1 | M | 9.9 | 38.7 | M2 | 46,XY,t(8;19)(q22;p13) or t(8;19;21)(q22;p13;q22)[20] | Non-CR | − | Primary disease |
| 209 | CBFB-MYH11 | FLT3-ITD | M | 16.2 | 172.2 | M4Eo | 48,XY,+6,+8,inv(16)(p13q22)[8]/49, sl,+21[5]/ 50, sl1,+10[5]/49, sl2, +8[2]/49, sl3,+11[2] | Induction death | − | Intracranial hemorrhage (day 16) |
| 26 | biallelic CEBPA | — | M | 6.8 | 10.7 | M1 | 46,XY[20] | Intermediate | − | ARDS |
| 97 | NPM1 | — | F | 11.6 | 38.2 | RAEB-T | 47,XX,+18[1]/46,XX[19] | Intermediate | + | Primary disease |