Mechanism of diagnosis and incidence of SMM diagnosis in optimally followed patients with high-risk MGUS
| Variable . | M spike ≥ 1.5 g/dL and/or non-IgG spike (n = 52; 65%) . | M spike < 1.5 g/dL and IgG spike (n = 27; 34%) . | P . |
|---|---|---|---|
| SMM diagnosis preceding symptomatic MM, n (%) | 20 (38) | 4 (15) | .04* |
| Mechanism of MM diagnosis, n (%) | |||
| Complications | 21 (40) | 14 (52) | .5 |
| Symptoms | 14 (27) | 6 (22) | .8 |
| Follow-up | 11 (21) | 2 (7) | .1 |
| Incidental | 4 (8) | 5 (19) | .3 |
| Not available | 2 (4) | 0 | NA |
| Variable . | M spike ≥ 1.5 g/dL and/or non-IgG spike (n = 52; 65%) . | M spike < 1.5 g/dL and IgG spike (n = 27; 34%) . | P . |
|---|---|---|---|
| SMM diagnosis preceding symptomatic MM, n (%) | 20 (38) | 4 (15) | .04* |
| Mechanism of MM diagnosis, n (%) | |||
| Complications | 21 (40) | 14 (52) | .5 |
| Symptoms | 14 (27) | 6 (22) | .8 |
| Follow-up | 11 (21) | 2 (7) | .1 |
| Incidental | 4 (8) | 5 (19) | .3 |
| Not available | 2 (4) | 0 | NA |
Patients with high-risk MGUS (M spike ≥ 1.5 g/dL and/or non-IgG spike) were significantly more likely to have a diagnosis of SMM preceding symptomatic MM. In addition, patients with high-risk MGUS had a 3-fold higher probability of being diagnosed with symptomatic MM secondary to abnormal laboratory findings compared with low-risk MGUS patients (21% vs 7%). MM diagnosis secondary to onset of MM-related complications or incidental findings was less likely for high-risk patients than low-risk patients (40% vs 52% and 8% vs 19%, respectively).
NA indicates not applicable.
Statistically significant.