Antiproliferative activity of AT9283 in a panel of BaF3 BCR-ABL cell lines
| BaF3 . | AT9283 IC50, nM . |
|---|---|
| Parental (BCR-ABL−) | 103 |
| wt p190 | 16 |
| wt p210 | 13 |
| Y253F | 16 |
| T315I | 11 |
| T315A | 10 |
| Q252H | 21 |
| M351T | 18 |
| M294V | 18 |
| H396P | 21 |
| G250E | 12 |
| F317V | 14 |
| F317L | 15 |
| E255K | 13 |
| BaF3 . | AT9283 IC50, nM . |
|---|---|
| Parental (BCR-ABL−) | 103 |
| wt p190 | 16 |
| wt p210 | 13 |
| Y253F | 16 |
| T315I | 11 |
| T315A | 10 |
| Q252H | 21 |
| M351T | 18 |
| M294V | 18 |
| H396P | 21 |
| G250E | 12 |
| F317V | 14 |
| F317L | 15 |
| E255K | 13 |
Y253F indicates tyrosine 253 to phenylalanine; T315A, threonine 315 to alanine; Q252H, glutamine 252 to histidine; M351T, methionine 351 to threonine; M294V, methionine 294 to valine; H396P, histidine 396 to proline; G250E, glycine 250 to glutamic acid; F317V, phenylalanine 317 to valine; and F317L, phenylalanine 317 to leucine.