Frequencies of gains and losses of molecular aberrations in pediatric AML (n = 69)
| Type of change . | Gene of interest . | ||||||
|---|---|---|---|---|---|---|---|
| FLT3/ITD (n = 63) . | FLT3 D835 (n = 50) . | RAS (n = 52) . | KIT (n = 27) . | WT1 (n = 42) . | NPM1 (n = 68) . | CEBPA (n = 30) . | |
| Gain at relapse | 2 | 1 | 4 | 0 | 5 | 0 | 1 |
| Loss at relapse | 4 | 1 | 7 | 0 | 0 | 1 | 0 |
| Total no. of changes (%) | 6 (9.5) | 2 (4) | 11 (21) | 0 (0) | 5 (12) | 1 (1.5) | 1 (1.5) |
| Type of change . | Gene of interest . | ||||||
|---|---|---|---|---|---|---|---|
| FLT3/ITD (n = 63) . | FLT3 D835 (n = 50) . | RAS (n = 52) . | KIT (n = 27) . | WT1 (n = 42) . | NPM1 (n = 68) . | CEBPA (n = 30) . | |
| Gain at relapse | 2 | 1 | 4 | 0 | 5 | 0 | 1 |
| Loss at relapse | 4 | 1 | 7 | 0 | 0 | 1 | 0 |
| Total no. of changes (%) | 6 (9.5) | 2 (4) | 11 (21) | 0 (0) | 5 (12) | 1 (1.5) | 1 (1.5) |
n indicates the number of paired samples that could be analyzed for this mutation.