Table 2 Drugs with evidence for... | American Society of Hematology

Table 2

Drugs with evidence for association with thrombocytopenia by clinical data in published case reports and identification of drug-dependent, platelet-reactive antibodies, and/or data mining of the AERS database

Drug	Methods of association with thrombocytopenia
Drug	Case reports, laboratory testing, and data mining	Case reports and laboratory testing only
Abciximab*†	+
Acetaminophen‡	+
Amiodarone	−	+
Ampicillin	+
Carbamazepine*†	+
Eptifibatide†	+
Ethambutol	+
Haloperidol	+
Ibuprofen‡	+
Irinotecan	+
Naproxen‡	+
Oxaliplatin	+
Phenytoin†	+
Piperacillin†	+
Quinidine*†	+
Quinine*†	+
Ranitidine	+
Rifampin*†	+
Simvastatin	+
Sulfisoxazole	+
Tirofiban†	+
Trimethoprim-sulfamethoxazole*†	+
Valproic acid	+
Vancomycin†	+

Drug	Methods of association with thrombocytopenia
Drug	Case reports, laboratory testing, and data mining	Case reports and laboratory testing only
Abciximab*†	+
Acetaminophen‡	+
Amiodarone	−	+
Ampicillin	+
Carbamazepine*†	+
Eptifibatide†	+
Ethambutol	+
Haloperidol	+
Ibuprofen‡	+
Irinotecan	+
Naproxen‡	+
Oxaliplatin	+
Phenytoin†	+
Piperacillin†	+
Quinidine*†	+
Quinine*†	+
Ranitidine	+
Rifampin*†	+
Simvastatin	+
Sulfisoxazole	+
Tirofiban†	+
Trimethoprim-sulfamethoxazole*†	+
Valproic acid	+
Vancomycin†	+

Twenty-four drugs with evidence for a causal association with thrombocytopenia by both clinical data from published case reports and by identification of drug-dependent, platelet-reactive antibodies are listed. Twenty-three of these drugs also had a statistically significant reporting association with thrombocytopenia by data mining of the AERS database.

These 6 drugs had clinical evidence for a causal association with thrombocytopenia in 10 or more case reports.

†

These 11 drugs had evidence for a causal association with thrombocytopenia by detection of drug-dependent, platelet reactive antibodies in 10 or more patients.

‡

For acetaminophen and naproxen, drug-dependent antibodies have been identified only for metabolites and do not react with the unmodified drug. For ibuprofen, drug-dependent antibodies that reacted with the unmodified drug have been identified in some patients; in other patients, drug-dependent antibodies only reacted with metabolites of ibuprofen.

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