Table 1 Required criteria Chronic... | American Society of Hematology

Table 1

Required criteria

Chronic nonmalignant lymphadenopathy and/or splenomegaly

Increased peripheral CD3⁺TCRαβ⁺CD4⁻CD8⁻ (DNT) cells

Lymphocyte apoptosis defect

Supporting criteria

Family history of ALPS

Characteristic histopathology

Autoimmune manifestations