Relative risk of selected fractures after a diagnosis of MGUS compared with matched controls
| Disease/grouping . | 5-y follow-up . | 10-y follow-up . | ||||
|---|---|---|---|---|---|---|
| MGUS (n = 5326) . | Ctrl (n = 20 161) . | HR* (95% CI) . | MGUS . | Ctrl . | HR* (95% CI) . | |
| Any fracture (combined) | ||||||
| All patients | 569 | 1461 | 1.74 (1.58-1.92) | 880 | 2455 | 1.61 (1.49-1.74) |
| Men | 222 | 519 | 1.89 (1.61-2.21) | 337 | 874 | 1.71 (1.51-1.94) |
| Women | 347 | 942 | 1.66 (1.47-1.88) | 543 | 1581 | 1.56 (1.42-1.72) |
| Specific fractures | ||||||
| Skull fracture | 15 | 52 | 1.22 (0.69-2.17) | 23 | 81 | 1.20 (0.76-1.91) |
| Vertebral/pelvis fracture | 155 | 255 | 2.67 (2.18-3.26) | 231 | 435 | 2.37 (2.02-2.78) |
| Sternum/costae fracture | 52 | 109 | 2.06 (1.48-2.87) | 87 | 197 | 1.93 (1.50-2.48) |
| Arm fracture | 130 | 399 | 1.38 (1.13-1.69) | 224 | 777 | 1.23 (1.06-1.43) |
| Leg fracture | 279 | 807 | 1.53 (1.33-1.75) | 439 | 1394 | 1.40 (1.26-1.56) |
| Other/multiple bone fractures | 78 | 71 | 4.55 (3.30-6.27) | 116 | 115 | 4.25 (3.29-5.51) |
| Disease/grouping . | 5-y follow-up . | 10-y follow-up . | ||||
|---|---|---|---|---|---|---|
| MGUS (n = 5326) . | Ctrl (n = 20 161) . | HR* (95% CI) . | MGUS . | Ctrl . | HR* (95% CI) . | |
| Any fracture (combined) | ||||||
| All patients | 569 | 1461 | 1.74 (1.58-1.92) | 880 | 2455 | 1.61 (1.49-1.74) |
| Men | 222 | 519 | 1.89 (1.61-2.21) | 337 | 874 | 1.71 (1.51-1.94) |
| Women | 347 | 942 | 1.66 (1.47-1.88) | 543 | 1581 | 1.56 (1.42-1.72) |
| Specific fractures | ||||||
| Skull fracture | 15 | 52 | 1.22 (0.69-2.17) | 23 | 81 | 1.20 (0.76-1.91) |
| Vertebral/pelvis fracture | 155 | 255 | 2.67 (2.18-3.26) | 231 | 435 | 2.37 (2.02-2.78) |
| Sternum/costae fracture | 52 | 109 | 2.06 (1.48-2.87) | 87 | 197 | 1.93 (1.50-2.48) |
| Arm fracture | 130 | 399 | 1.38 (1.13-1.69) | 224 | 777 | 1.23 (1.06-1.43) |
| Leg fracture | 279 | 807 | 1.53 (1.33-1.75) | 439 | 1394 | 1.40 (1.26-1.56) |
| Other/multiple bone fractures | 78 | 71 | 4.55 (3.30-6.27) | 116 | 115 | 4.25 (3.29-5.51) |
HR indicates hazard ratio; CI, confidence interval; and ctrl, controls.
Adjusted for age, sex, and calendar period.