IC50 values of Ba/F3 cells expressing FLT3-ITD and mutant isoforms in the presence of AC220, sorafenib, ponatinib, or DCC-2036
| Mutation . | IC50 for cellular proliferation (nM) . | |||
|---|---|---|---|---|
| AC220 . | Sorafenib . | Ponatinib . | DCC-2036 . | |
| Parental + IL3 | >1000 | 3761 | >1000 | >5000 |
| ITD alone | 0.13 | 1.3 | 3.0 | 19 |
| ITD + F691L | 102 | 1189 | 52 | 49 |
| ITD + F691I | 122 | 648 | 4.2 | 51 |
| ITD + D835V | 120 | 2209 | 349 | 255 |
| ITD + D835Y | 28 | 675 | 284 | 315 |
| ITD + D835F | 166 | 2374 | 414 | 1417 |
| ITD + D835H | 5.5 | 164 | 211 | 148 |
| ITD + D839G | 1.9 | 112 | 54 | 51 |
| ITD + Y842C | 33 | 469 | 229 | 47 |
| ITD + Y842H | 18 | 260 | 80 | 30 |
| Mutation . | IC50 for cellular proliferation (nM) . | |||
|---|---|---|---|---|
| AC220 . | Sorafenib . | Ponatinib . | DCC-2036 . | |
| Parental + IL3 | >1000 | 3761 | >1000 | >5000 |
| ITD alone | 0.13 | 1.3 | 3.0 | 19 |
| ITD + F691L | 102 | 1189 | 52 | 49 |
| ITD + F691I | 122 | 648 | 4.2 | 51 |
| ITD + D835V | 120 | 2209 | 349 | 255 |
| ITD + D835Y | 28 | 675 | 284 | 315 |
| ITD + D835F | 166 | 2374 | 414 | 1417 |
| ITD + D835H | 5.5 | 164 | 211 | 148 |
| ITD + D839G | 1.9 | 112 | 54 | 51 |
| ITD + Y842C | 33 | 469 | 229 | 47 |
| ITD + Y842H | 18 | 260 | 80 | 30 |