IC50 values of Ba/F3 cells expressing FLT3-ITD/F691L mutant isoforms in the presence of ponatinib
| Mutation . | IC50 for cellular proliferation (nM) . |
|---|---|
| Parental + IL3 | >1000 |
| ITD alone | 2.5 |
| ITD + F691L | 61 |
| ITD + F691L/D835V | 632 |
| ITD + F691L/D835Y | 409 |
| ITD + F691L/D835F | 742 |
| ITD + F691L/D835H | 300 |
| ITD + F691L/D839G | 393 |
| ITD + F691L/Y842C | 344 |
| ITD + F691L/Y842H | 379 |
| Mutation . | IC50 for cellular proliferation (nM) . |
|---|---|
| Parental + IL3 | >1000 |
| ITD alone | 2.5 |
| ITD + F691L | 61 |
| ITD + F691L/D835V | 632 |
| ITD + F691L/D835Y | 409 |
| ITD + F691L/D835F | 742 |
| ITD + F691L/D835H | 300 |
| ITD + F691L/D839G | 393 |
| ITD + F691L/Y842C | 344 |
| ITD + F691L/Y842H | 379 |