Gene products found in 2 or more pathways significantly affected by the expression of RPS19R62W in basophilic erythroblasts
| Gene symbol . | Gene name . | RNA level, fold* . | Function(s) . |
|---|---|---|---|
| Wdr33 | WD repeat domain 33 | ↓1.6 | Protein binding, post replication repair |
| Txnrd1 | Thioredoxin reductase 1 | ↓1.6 | Oxidative stress response, cell proliferation, amino acid metabolism |
| Trp53 | Tumor protein p53 | ↑1.7 | Apoptosis |
| Tjp2 | Tight junction protein 2 | ↑1.55 | Intercellular junctions |
| Tgfbr2 | TGF-β receptor II | ↑2.2 | Vasculogenesis, embryonic hematopoiesis, inflammation |
| Tfrc | Transferrin receptor | ↓2.1 | Cellular iron homeostasis, endocytosis |
| Strap | Serine/threonine kinase | ↑1.6 | mRNA processing, RNA splicing |
| receptor associated protein | |||
| Sfrs10 | Splicing factor, argenine/serine-rich 10 | ↓1.6 | mRNA processing, RNA splicing |
| Sf3a1 | Splicing factor 3a subunit 1 | ↑1.8 | mRNA processing, RNA splicing, protein modification |
| Pmm1 | Phosphomannomutase 1 | ↑1.9 | Metabolism, mannose biosynthesis |
| Phlda2 | Pleckstrin homology-like domain a2 | ↓1.5 | Apoptosis, organ morphogenesis |
| Pfn1 | Profilin 1 | ↓2.2 | Regulation of RNA pol II transcription, actin binding, cytoskeleton organization |
| Pcyt1a | Phosphate cytidyltransferase 1, choline-α | ↓1.6 | Phosphatidylcholine and phospholipid biosynthesis, membrane expansion |
| Oat | Ornithine aminotransferase | NC | Neurotransmitter metabolism |
| Nfya | Nuclear transcription factor Yα | ↓2.1 | Regulation of RNA pol II transcription |
| Myo1c | Myosin 1C | ↑1.6 | Regulation of RNA pol II transcription, transport |
| Mknk2 | MAP kinase interacting serine/threonine kinase 2 | ↓1.6 | Regulation of translation, amino acid phosphorylation, stress response |
| Kif23 | Kinesin family member 23 | ↓1.6 | Mitosis, cell division |
| Itgb4 | Integrin β4 | ↑1.8 | Cell communication/adhesion, integrin signaling |
| Hspe1 | Heat shock protein 1 | ↓1.5 | Protein folding, apoptosis |
| Hsp27 | Heat shock protein 27 | NC | Apoptosis |
| Hnf4a | Hepatocyte nuclear factor 4α | NC | Regulation of RNA pol II transcription, cell |
| Hk2 | Hexokinase 2 | NC | Glycolosis, carbohydrate phosphorylation proliferation, metabolism |
| Gmfb | Glia maturation factor-β | ↓1.8 | Oxidative stress response, apoptosis |
| Gclc | Glutamate-cystine ligase | NC | Oxidative stress response, apoptosis, regulation of RNA pol II transcription |
| Eif2s1 | Eukaryotic translation initiation factor 2, subunit 1α | ↓6.3 | Regulation of translation |
| Eda | Ectodysplasin A | ↓1.5 | Regulator of NF-κB activity |
| Dyrk1a | Dual-specificity tyrosine phosphorylation-regulated kinase 1A | ↓3.0 | Tyrosine, serine/threonine phosphorylation |
| Cyb5r3 | Cytochrome B5 reductase 3 | ↓2.2 | Oxidation reduction, cholesterol biosynthesis |
| Csh1 | Chorionic somatomammotripin | NC | signal transduction, hormonal activity |
| Cd47 | CD47 molecule | ↑2.0 | Cell adhesion, proliferation, regulator of thrombospondin receptor, integrin signaling |
| Ccr1 | Chemokine receptor 1 | ↑2.6 | Cell adhesion, chemokine signaling |
| Brd2 | Bromodomain containing 2 | ↑1.5 | Serine/threonine kinase, spermatogenesis |
| Atpase | ATPase | ↑1.7 | Purine metabolism, cell proliferation |
| Atp6v1g1 | ATPase, H+ transporting Lysosomal, V1 sububit, G1 | ↓1.5 | Ion transport, proton transport |
| Acaa1b | Acetyl-coenzyme A, acetyltransferase 1B | ↑2.4 | Metabolism |
| Acaa2 | Acetyl-coenzyme A, acetyltransferase 2 | ↓1.6 | Metabolism, cholesterol biosynthesis |
| Gene symbol . | Gene name . | RNA level, fold* . | Function(s) . |
|---|---|---|---|
| Wdr33 | WD repeat domain 33 | ↓1.6 | Protein binding, post replication repair |
| Txnrd1 | Thioredoxin reductase 1 | ↓1.6 | Oxidative stress response, cell proliferation, amino acid metabolism |
| Trp53 | Tumor protein p53 | ↑1.7 | Apoptosis |
| Tjp2 | Tight junction protein 2 | ↑1.55 | Intercellular junctions |
| Tgfbr2 | TGF-β receptor II | ↑2.2 | Vasculogenesis, embryonic hematopoiesis, inflammation |
| Tfrc | Transferrin receptor | ↓2.1 | Cellular iron homeostasis, endocytosis |
| Strap | Serine/threonine kinase | ↑1.6 | mRNA processing, RNA splicing |
| receptor associated protein | |||
| Sfrs10 | Splicing factor, argenine/serine-rich 10 | ↓1.6 | mRNA processing, RNA splicing |
| Sf3a1 | Splicing factor 3a subunit 1 | ↑1.8 | mRNA processing, RNA splicing, protein modification |
| Pmm1 | Phosphomannomutase 1 | ↑1.9 | Metabolism, mannose biosynthesis |
| Phlda2 | Pleckstrin homology-like domain a2 | ↓1.5 | Apoptosis, organ morphogenesis |
| Pfn1 | Profilin 1 | ↓2.2 | Regulation of RNA pol II transcription, actin binding, cytoskeleton organization |
| Pcyt1a | Phosphate cytidyltransferase 1, choline-α | ↓1.6 | Phosphatidylcholine and phospholipid biosynthesis, membrane expansion |
| Oat | Ornithine aminotransferase | NC | Neurotransmitter metabolism |
| Nfya | Nuclear transcription factor Yα | ↓2.1 | Regulation of RNA pol II transcription |
| Myo1c | Myosin 1C | ↑1.6 | Regulation of RNA pol II transcription, transport |
| Mknk2 | MAP kinase interacting serine/threonine kinase 2 | ↓1.6 | Regulation of translation, amino acid phosphorylation, stress response |
| Kif23 | Kinesin family member 23 | ↓1.6 | Mitosis, cell division |
| Itgb4 | Integrin β4 | ↑1.8 | Cell communication/adhesion, integrin signaling |
| Hspe1 | Heat shock protein 1 | ↓1.5 | Protein folding, apoptosis |
| Hsp27 | Heat shock protein 27 | NC | Apoptosis |
| Hnf4a | Hepatocyte nuclear factor 4α | NC | Regulation of RNA pol II transcription, cell |
| Hk2 | Hexokinase 2 | NC | Glycolosis, carbohydrate phosphorylation proliferation, metabolism |
| Gmfb | Glia maturation factor-β | ↓1.8 | Oxidative stress response, apoptosis |
| Gclc | Glutamate-cystine ligase | NC | Oxidative stress response, apoptosis, regulation of RNA pol II transcription |
| Eif2s1 | Eukaryotic translation initiation factor 2, subunit 1α | ↓6.3 | Regulation of translation |
| Eda | Ectodysplasin A | ↓1.5 | Regulator of NF-κB activity |
| Dyrk1a | Dual-specificity tyrosine phosphorylation-regulated kinase 1A | ↓3.0 | Tyrosine, serine/threonine phosphorylation |
| Cyb5r3 | Cytochrome B5 reductase 3 | ↓2.2 | Oxidation reduction, cholesterol biosynthesis |
| Csh1 | Chorionic somatomammotripin | NC | signal transduction, hormonal activity |
| Cd47 | CD47 molecule | ↑2.0 | Cell adhesion, proliferation, regulator of thrombospondin receptor, integrin signaling |
| Ccr1 | Chemokine receptor 1 | ↑2.6 | Cell adhesion, chemokine signaling |
| Brd2 | Bromodomain containing 2 | ↑1.5 | Serine/threonine kinase, spermatogenesis |
| Atpase | ATPase | ↑1.7 | Purine metabolism, cell proliferation |
| Atp6v1g1 | ATPase, H+ transporting Lysosomal, V1 sububit, G1 | ↓1.5 | Ion transport, proton transport |
| Acaa1b | Acetyl-coenzyme A, acetyltransferase 1B | ↑2.4 | Metabolism |
| Acaa2 | Acetyl-coenzyme A, acetyltransferase 2 | ↓1.6 | Metabolism, cholesterol biosynthesis |
NC indicates no significant change in mRNA levels, gene product imported with significantly affected pathway.
Significant change (P < .03) in mRNA levels.