Deregulation of Wnt pathway gene expression in CLL
| Gene name . | Fold change . | Role in Wnt signaling . |
|---|---|---|
| LEF1 | 28-fold higher in CLL | Pathway transcription factor; target gene |
| IGFBP4 | 19-fold higher in CLL | Secreted pathway inhibitor |
| WNT3 | 6.4-fold higher in CLL | Secreted pathway ligand |
| TCF4 (ITF2) | 4-fold higher in CLL | Target gene |
| JUN | 3.2-fold higher in control | Nuclear regulator |
| CCND2 | 2.4-fold higher in CLL | Target gene |
| CTBP2 | 2.2-fold higher in control | Corepressor of Wnt target genes |
| CSNK1D | 1.9-fold higher in control | Pathway kinase |
| Gene name . | Fold change . | Role in Wnt signaling . |
|---|---|---|
| LEF1 | 28-fold higher in CLL | Pathway transcription factor; target gene |
| IGFBP4 | 19-fold higher in CLL | Secreted pathway inhibitor |
| WNT3 | 6.4-fold higher in CLL | Secreted pathway ligand |
| TCF4 (ITF2) | 4-fold higher in CLL | Target gene |
| JUN | 3.2-fold higher in control | Nuclear regulator |
| CCND2 | 2.4-fold higher in CLL | Target gene |
| CTBP2 | 2.2-fold higher in control | Corepressor of Wnt target genes |
| CSNK1D | 1.9-fold higher in control | Pathway kinase |
P < .0001 for all.