Table 1

Multivariate prognostic factor analyses for allografted patients

Endpoint and variableMultivariate analysis
P valueHRLowerCLUpperCL
Overall survival     
 TCD vs no TCD .004 3.46 1.49 8.04 
 Refractory at HSCT vs sensitive .042 2.40 1.03 5.56 
 Fludara refractory vs sensitive .13 2.61 0.75 9.16 
 Age (per year) .36 0.98 0.93 1.03 
 TP53 mutated vs unmutated .91 1.05 0.44 2.50 
 SF3B1 mutated vs unmutated .60 0.79 0.33 1.88 
 NOTCH1 mutated vs unmutated .53 0.69 0.22 2.16 
Event-free survival     
 TCD vs no TCD .004 2.79 1.39 5.60 
 Refractory at HSCT vs sensitive .002 3.13 1.53 6.38 
 Fludara refractory vs sensitive .93 1.04 0.46 2.32 
 Age (per year) .22 0.98 0.94 1.02 
 TP53 mutated vs unmutated .25 0.66 0.32 1.34 
 SF3B1 mutated vs unmutated .21 0.63 0.32 1.29 
 NOTCH1 mutated vs unmutated .42 0.68 0.27 1.74 
Endpoint and variableMultivariate analysis
P valueHRLowerCLUpperCL
Overall survival     
 TCD vs no TCD .004 3.46 1.49 8.04 
 Refractory at HSCT vs sensitive .042 2.40 1.03 5.56 
 Fludara refractory vs sensitive .13 2.61 0.75 9.16 
 Age (per year) .36 0.98 0.93 1.03 
 TP53 mutated vs unmutated .91 1.05 0.44 2.50 
 SF3B1 mutated vs unmutated .60 0.79 0.33 1.88 
 NOTCH1 mutated vs unmutated .53 0.69 0.22 2.16 
Event-free survival     
 TCD vs no TCD .004 2.79 1.39 5.60 
 Refractory at HSCT vs sensitive .002 3.13 1.53 6.38 
 Fludara refractory vs sensitive .93 1.04 0.46 2.32 
 Age (per year) .22 0.98 0.94 1.02 
 TP53 mutated vs unmutated .25 0.66 0.32 1.34 
 SF3B1 mutated vs unmutated .21 0.63 0.32 1.29 
 NOTCH1 mutated vs unmutated .42 0.68 0.27 1.74 

Missing values (TCD 0; Refractory/ sensitive at HSCT 1; Fludara refractory/sensitive 31; age 0; TP53/17p abn 17; SF3B1 mut 19; NOTCH1 mut 19) were considered as individual category for each covariate. Results of missing value categories are not included in the table.

CL, confidence limit; TCD, in vivo T-cell depletion with alemtuzumab.

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