Hexon modifications introduced in FX-binding ablated Ad5 vectors
| Virus nomenclature . | Promoter and transgene . | Hexon modification . |
|---|---|---|
| Ad5 | CMVlacZ | Wild-type Ad5 |
| Ad5-HVR5(Ad26) | CMVlacZ | Ad5HVR5 swapped for Ad26 |
| Ad5-HVR7(Ad26) | CMVlacZ | Ad5HVR7 swapped for Ad26 |
| Ad5-HVR5+7(Ad26) | CMVlacZ | Ad5HVR5+7 swapped for Ad26 |
| Ad5-HVR5* | CMVlacZ | HVR5 (T270P and E271G) |
| Ad5-HVR7* | CMVlacZ | HVR7 (I421G, T423N, E424S, L426Y) |
| Ad5-E451Q | CMVlacZ | HVR7(E451Q) |
| Ad5-HVR5*7*E451Q | CMVlacZ | HVR5 (T270P and E271G) and HVR7 (I421G, T423N, E424S, L426Y and E451Q) |
| Virus nomenclature . | Promoter and transgene . | Hexon modification . |
|---|---|---|
| Ad5 | CMVlacZ | Wild-type Ad5 |
| Ad5-HVR5(Ad26) | CMVlacZ | Ad5HVR5 swapped for Ad26 |
| Ad5-HVR7(Ad26) | CMVlacZ | Ad5HVR7 swapped for Ad26 |
| Ad5-HVR5+7(Ad26) | CMVlacZ | Ad5HVR5+7 swapped for Ad26 |
| Ad5-HVR5* | CMVlacZ | HVR5 (T270P and E271G) |
| Ad5-HVR7* | CMVlacZ | HVR7 (I421G, T423N, E424S, L426Y) |
| Ad5-E451Q | CMVlacZ | HVR7(E451Q) |
| Ad5-HVR5*7*E451Q | CMVlacZ | HVR5 (T270P and E271G) and HVR7 (I421G, T423N, E424S, L426Y and E451Q) |