EC50 of JAK2 inhibitors in HL and MLBCL cell lines
| . | JAK2 copy number . | SD-1029 . | Z3 . | ||
|---|---|---|---|---|---|
| EC50 . | 95% CI . | EC50 . | 95% CI . | ||
| L428 | 2.46 | 10.7 | 10.4-10.9 | 10.1 | 9.9-10.3 |
| L540 | 2.84 | 4.7 | 4.5-4.9 | 5.2 | 5.1-5.3 |
| KMH2 | 2.84 | 4.7 | 4.6-4.9 | 4.9 | 4.6-5.1 |
| L1236 | 3.60 | 4.3 | 3.9-4.7 | 2.5 | 2.1-2.8 |
| SUPHD1 | 4.83 | 3.1 | 3.0-3.3 | 1.7 | 1.4-1.9 |
| HDLM2 | 7.36 | 3.0 | 2.9-3.0 | 2.7 | 2.3-3.1 |
| Karpas-1106P | 3.82 | 1.7 | 1.6-1.7 | 3.2 | 2.9-3.5 |
| . | JAK2 copy number . | SD-1029 . | Z3 . | ||
|---|---|---|---|---|---|
| EC50 . | 95% CI . | EC50 . | 95% CI . | ||
| L428 | 2.46 | 10.7 | 10.4-10.9 | 10.1 | 9.9-10.3 |
| L540 | 2.84 | 4.7 | 4.5-4.9 | 5.2 | 5.1-5.3 |
| KMH2 | 2.84 | 4.7 | 4.6-4.9 | 4.9 | 4.6-5.1 |
| L1236 | 3.60 | 4.3 | 3.9-4.7 | 2.5 | 2.1-2.8 |
| SUPHD1 | 4.83 | 3.1 | 3.0-3.3 | 1.7 | 1.4-1.9 |
| HDLM2 | 7.36 | 3.0 | 2.9-3.0 | 2.7 | 2.3-3.1 |
| Karpas-1106P | 3.82 | 1.7 | 1.6-1.7 | 3.2 | 2.9-3.5 |
Values are reported as the median and 95% confidence interval of the concentration (μM) of inhibitor required to elicit a 50% reduction in cellular proliferation/respiration.