Table 2

Results of multivariate analysis of outcomes in 386 cord blood transplantations

Hazard ratio95% CIP
Neutrophil recovery ab-negative 1.00   
 ab-positive 0.69 (0.49-0.96) .027 
 positive-vs-CB 0.23 (0.09-0.56) .001 
 positive-vs-CB vs ab-positive 0.31 (0.12-0.80) .015 
Platelet recovery ab-negative 1.00   
 ab-positive 0.73 (0.49-1.07) .11 
 positive-vs-CB 0.31 (0.12-0.81) .017 
 positive-vs-CB vs ab-positive 0.35 (0.11-1.10) .071 
Grade II-IV acute GVHD ab-negative 1.00   
 ab-positive 0.76 (0.44-1.30) .31 
 positive-vs-CB 0.49 (0.13-1.78) .28 
 positive-vs-CB vs ab-positive 0.79 (0.19-3.20) .74 
Relapse ab-negative 1.00   
 ab-positive 1.98 (1.14-3.43) .015 
 positive-vs-CB 1.75 (0.73-4.21) .21 
 positive-vs-CB vs ab-positive 0.69 (0.24-1.97) .48 
Transplant-related mortality ab-negative 1.00   
 ab-positive 0.94 (0.55-1.60) .81 
 positive-vs-CB 2.06 (0.96-4.43) .064 
 positive-vs-CB vs ab-positive 3.82 (1.37-10.71) .0011 
Treatment failure (EFS) ab-negative 1.00   
 ab-positive 1.53 (1.07-2.19) .021 
 positive-vs-CB 3.46 (2.01-5.96) < .001 
 positive-vs-CB vs ab-positive 2.30 (1.20-4.43) .012 
Overall mortality (OS) ab-negative 1.00   
 ab-positive 1.33 (0.86-2.04) .20 
 positive-vs-CB 2.33 (1.18-4.59) .015 
 positive-vs-CB vs ab-positive 1.99 (0.85-4.70) .12 
Hazard ratio95% CIP
Neutrophil recovery ab-negative 1.00   
 ab-positive 0.69 (0.49-0.96) .027 
 positive-vs-CB 0.23 (0.09-0.56) .001 
 positive-vs-CB vs ab-positive 0.31 (0.12-0.80) .015 
Platelet recovery ab-negative 1.00   
 ab-positive 0.73 (0.49-1.07) .11 
 positive-vs-CB 0.31 (0.12-0.81) .017 
 positive-vs-CB vs ab-positive 0.35 (0.11-1.10) .071 
Grade II-IV acute GVHD ab-negative 1.00   
 ab-positive 0.76 (0.44-1.30) .31 
 positive-vs-CB 0.49 (0.13-1.78) .28 
 positive-vs-CB vs ab-positive 0.79 (0.19-3.20) .74 
Relapse ab-negative 1.00   
 ab-positive 1.98 (1.14-3.43) .015 
 positive-vs-CB 1.75 (0.73-4.21) .21 
 positive-vs-CB vs ab-positive 0.69 (0.24-1.97) .48 
Transplant-related mortality ab-negative 1.00   
 ab-positive 0.94 (0.55-1.60) .81 
 positive-vs-CB 2.06 (0.96-4.43) .064 
 positive-vs-CB vs ab-positive 3.82 (1.37-10.71) .0011 
Treatment failure (EFS) ab-negative 1.00   
 ab-positive 1.53 (1.07-2.19) .021 
 positive-vs-CB 3.46 (2.01-5.96) < .001 
 positive-vs-CB vs ab-positive 2.30 (1.20-4.43) .012 
Overall mortality (OS) ab-negative 1.00   
 ab-positive 1.33 (0.86-2.04) .20 
 positive-vs-CB 2.33 (1.18-4.59) .015 
 positive-vs-CB vs ab-positive 1.99 (0.85-4.70) .12 

CI indicates confidence interval; GVHD, graft-versus-host disease; ab-negative, patient does not have anti-HLA antibody; ab-positive, patient has anti-HLA antibody but the CB does not have the corresponding antigen for the antibody specificity; and positive-vs-CB, patient has anti-HLA antibody and the CB has the corresponding antigen for the antibody specificity.

For neutrophil recovery, other significant variables were CD34+ cell dose ≤ 0.85 × 105/kg, no usage of G-CSF, advanced disease status and diagnosis of MDS or AML with multilineage dysplasia.

For platelet recovery, other significant variables were advanced disease status, CD34+ cell dose ≤ 0.85 × 05/kg and GVHD prophylaxis without MTX.

For acute GVHD of grade II-IV, other significant variables were diagnosis of lymphoproliferative disease and CD34+ cell dose ≤ 0.85 × 105/kg.

For relapse, other significant variables were advanced disease status and patient's sex being male.

For transplant-related mortality, other significant variables were patient age more than 45 years at transplantation, GVHD prophylaxis without MTX and cyclosporin-based GVHD prophylaxis compared with tacrolimus-based GVHD prophylaxis.

For treatment failure (as a reverse of event-free survival), other significant variables were advanced disease status, patient age more than 45 years at transplantation, diagnosis of lymphoproliferative disease and GVHD prophylaxis without MTX.

For overall mortality (as a reverse of overall survival), other significant variables were advanced disease status, patient age more than 45 years at transplantation and GVHD prophylaxis without MTX.

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