Results of multivariate analysis of outcomes in 386 cord blood transplantations
. | . | Hazard ratio . | 95% CI . | P . |
---|---|---|---|---|
Neutrophil recovery | ab-negative | 1.00 | ||
ab-positive | 0.69 | (0.49-0.96) | .027 | |
positive-vs-CB | 0.23 | (0.09-0.56) | .001 | |
positive-vs-CB vs ab-positive | 0.31 | (0.12-0.80) | .015 | |
Platelet recovery | ab-negative | 1.00 | ||
ab-positive | 0.73 | (0.49-1.07) | .11 | |
positive-vs-CB | 0.31 | (0.12-0.81) | .017 | |
positive-vs-CB vs ab-positive | 0.35 | (0.11-1.10) | .071 | |
Grade II-IV acute GVHD | ab-negative | 1.00 | ||
ab-positive | 0.76 | (0.44-1.30) | .31 | |
positive-vs-CB | 0.49 | (0.13-1.78) | .28 | |
positive-vs-CB vs ab-positive | 0.79 | (0.19-3.20) | .74 | |
Relapse | ab-negative | 1.00 | ||
ab-positive | 1.98 | (1.14-3.43) | .015 | |
positive-vs-CB | 1.75 | (0.73-4.21) | .21 | |
positive-vs-CB vs ab-positive | 0.69 | (0.24-1.97) | .48 | |
Transplant-related mortality | ab-negative | 1.00 | ||
ab-positive | 0.94 | (0.55-1.60) | .81 | |
positive-vs-CB | 2.06 | (0.96-4.43) | .064 | |
positive-vs-CB vs ab-positive | 3.82 | (1.37-10.71) | .0011 | |
Treatment failure (EFS) | ab-negative | 1.00 | ||
ab-positive | 1.53 | (1.07-2.19) | .021 | |
positive-vs-CB | 3.46 | (2.01-5.96) | < .001 | |
positive-vs-CB vs ab-positive | 2.30 | (1.20-4.43) | .012 | |
Overall mortality (OS) | ab-negative | 1.00 | ||
ab-positive | 1.33 | (0.86-2.04) | .20 | |
positive-vs-CB | 2.33 | (1.18-4.59) | .015 | |
positive-vs-CB vs ab-positive | 1.99 | (0.85-4.70) | .12 |
. | . | Hazard ratio . | 95% CI . | P . |
---|---|---|---|---|
Neutrophil recovery | ab-negative | 1.00 | ||
ab-positive | 0.69 | (0.49-0.96) | .027 | |
positive-vs-CB | 0.23 | (0.09-0.56) | .001 | |
positive-vs-CB vs ab-positive | 0.31 | (0.12-0.80) | .015 | |
Platelet recovery | ab-negative | 1.00 | ||
ab-positive | 0.73 | (0.49-1.07) | .11 | |
positive-vs-CB | 0.31 | (0.12-0.81) | .017 | |
positive-vs-CB vs ab-positive | 0.35 | (0.11-1.10) | .071 | |
Grade II-IV acute GVHD | ab-negative | 1.00 | ||
ab-positive | 0.76 | (0.44-1.30) | .31 | |
positive-vs-CB | 0.49 | (0.13-1.78) | .28 | |
positive-vs-CB vs ab-positive | 0.79 | (0.19-3.20) | .74 | |
Relapse | ab-negative | 1.00 | ||
ab-positive | 1.98 | (1.14-3.43) | .015 | |
positive-vs-CB | 1.75 | (0.73-4.21) | .21 | |
positive-vs-CB vs ab-positive | 0.69 | (0.24-1.97) | .48 | |
Transplant-related mortality | ab-negative | 1.00 | ||
ab-positive | 0.94 | (0.55-1.60) | .81 | |
positive-vs-CB | 2.06 | (0.96-4.43) | .064 | |
positive-vs-CB vs ab-positive | 3.82 | (1.37-10.71) | .0011 | |
Treatment failure (EFS) | ab-negative | 1.00 | ||
ab-positive | 1.53 | (1.07-2.19) | .021 | |
positive-vs-CB | 3.46 | (2.01-5.96) | < .001 | |
positive-vs-CB vs ab-positive | 2.30 | (1.20-4.43) | .012 | |
Overall mortality (OS) | ab-negative | 1.00 | ||
ab-positive | 1.33 | (0.86-2.04) | .20 | |
positive-vs-CB | 2.33 | (1.18-4.59) | .015 | |
positive-vs-CB vs ab-positive | 1.99 | (0.85-4.70) | .12 |
CI indicates confidence interval; GVHD, graft-versus-host disease; ab-negative, patient does not have anti-HLA antibody; ab-positive, patient has anti-HLA antibody but the CB does not have the corresponding antigen for the antibody specificity; and positive-vs-CB, patient has anti-HLA antibody and the CB has the corresponding antigen for the antibody specificity.
For neutrophil recovery, other significant variables were CD34+ cell dose ≤ 0.85 × 105/kg, no usage of G-CSF, advanced disease status and diagnosis of MDS or AML with multilineage dysplasia.
For platelet recovery, other significant variables were advanced disease status, CD34+ cell dose ≤ 0.85 × 05/kg and GVHD prophylaxis without MTX.
For acute GVHD of grade II-IV, other significant variables were diagnosis of lymphoproliferative disease and CD34+ cell dose ≤ 0.85 × 105/kg.
For relapse, other significant variables were advanced disease status and patient's sex being male.
For transplant-related mortality, other significant variables were patient age more than 45 years at transplantation, GVHD prophylaxis without MTX and cyclosporin-based GVHD prophylaxis compared with tacrolimus-based GVHD prophylaxis.
For treatment failure (as a reverse of event-free survival), other significant variables were advanced disease status, patient age more than 45 years at transplantation, diagnosis of lymphoproliferative disease and GVHD prophylaxis without MTX.
For overall mortality (as a reverse of overall survival), other significant variables were advanced disease status, patient age more than 45 years at transplantation and GVHD prophylaxis without MTX.