Analysis of HCV RNA, B-cell clonalities, and liver histology in different biologic compartments before PIRR therapy and at the end of follow-up in 7 responsive MC patients
| . | Start . | End of follow-up . |
|---|---|---|
| HCV RNA | ||
| Liver, IU/μg tissue, mean ± SD | 240 260 ± 180 600 | < detection limit |
| Bone marrow, IU/106 cells, mean ± SD | 166 440 ± 110 300 | < detection limit |
| Peripheral blood cells, IU/106 cells, mean ± SD | 196 800 ± 95 300 | < detection limit |
| B-cell clonal expansions, pattern/no. of bands | ||
| Liver | Oligoclonal/6 ± 2.6 | Polyclonal |
| Bone marrow | Oligoclonal/5 ± 3.1 | Polyclonal |
| Peripheral blood | Oligoclonal/6.3 ± 2.6 | Polyclonal |
| Liver histology | ||
| Inflammatory activity index | 6.2 ± 2.6 | 2.1 ± 0.6 |
| Grade of fibrosis | 2.2 ± 0.3 | 2.3 ± 0.5 |
| . | Start . | End of follow-up . |
|---|---|---|
| HCV RNA | ||
| Liver, IU/μg tissue, mean ± SD | 240 260 ± 180 600 | < detection limit |
| Bone marrow, IU/106 cells, mean ± SD | 166 440 ± 110 300 | < detection limit |
| Peripheral blood cells, IU/106 cells, mean ± SD | 196 800 ± 95 300 | < detection limit |
| B-cell clonal expansions, pattern/no. of bands | ||
| Liver | Oligoclonal/6 ± 2.6 | Polyclonal |
| Bone marrow | Oligoclonal/5 ± 3.1 | Polyclonal |
| Peripheral blood | Oligoclonal/6.3 ± 2.6 | Polyclonal |
| Liver histology | ||
| Inflammatory activity index | 6.2 ± 2.6 | 2.1 ± 0.6 |
| Grade of fibrosis | 2.2 ± 0.3 | 2.3 ± 0.5 |