Table 3 Features of IGH gene... | American Society of Hematology

Table 3

Features of IGH gene rearrangements in H^−/−/T^tg/wt (HT) and H^wt/wt/T^tg/wt (T) mouse clones

Animal no.	Tissue*	IGHV	HCDR3	Age, mo
HT225	PB,SP,BM	IGHV2-4-1	CARFYYSYYSYYAMDYW	7
HT25	PB†	IGHV2-9	CAKRLLRYYAMDYW	8
HT142	PB,SP,BM	IGHV11-1	CMRYGDYWYFDVW	9
HT109	PB,SP,BM	IGHV1-82	CARGGYPFVYW	13
HT119	PB,SP	IGHV1S61	CATGAWFAYW	13
T172	PB	IGHV12-3	CAGDGS#DYW	9
T214	PB	IGHV2-9-1	CARDDDYYYAMDYW	9
T87	SP	IGHV1-55	CAIGFDYW	13
T278	PB,SP,BM	IGHV2-2	CARNGYDYAMDYW	15
T348	PB,SP,BM	IGHV1-55	CARFYYYGSSYAMDYW	15
T382	SP	IGHV1-47	CAVYYVNFDYW	15

Animal no.	Tissue*	IGHV	HCDR3	Age, mo
HT225	PB,SP,BM	IGHV2-4-1	CARFYYSYYSYYAMDYW	7
HT25	PB†	IGHV2-9	CAKRLLRYYAMDYW	8
HT142	PB,SP,BM	IGHV11-1	CMRYGDYWYFDVW	9
HT109	PB,SP,BM	IGHV1-82	CARGGYPFVYW	13
HT119	PB,SP	IGHV1S61	CATGAWFAYW	13
T172	PB	IGHV12-3	CAGDGS#DYW	9
T214	PB	IGHV2-9-1	CARDDDYYYAMDYW	9
T87	SP	IGHV1-55	CAIGFDYW	13
T278	PB,SP,BM	IGHV2-2	CARNGYDYAMDYW	15
T348	PB,SP,BM	IGHV1-55	CARFYYYGSSYAMDYW	15
T382	SP	IGHV1-47	CAVYYVNFDYW	15

PB indicates peripheral blood; SP, spleen; and BM, bone marrow.

Only tissues analyzed and positive for the presence of an immunoglobulin rearrangement are listed.

SP and BM were not analyzed.

Indicates a stop codon, making the sequence unproductive.