Degree of variation in β3 βI-hybrid domain orientation among β3 integrin structures
| . | αIIbβ3closed headpiece* . | αIIbβ3 ectodomain (3FCS)* . | αVβ3 ectodomain (3IJE)† . | αVβ3 liganded ectodomain (1L5G)† . | αIIbβ3 open headpiece‡ . |
|---|---|---|---|---|---|
| αIIbβ3 closed headpiece* | 3.0° | 12.6°-13.3° | 11.5°-13.5° | 13.9°-15.9° | 51.3°-62.3° |
| αIIbβ3 ectodomain (3FCS)* | — | 0.2° | 7.4°-7.4° | 8.2°-8.3° | 57.9°-69.7° |
| αVβ3 ectodomain (3IJE)† | — | — | — | 1.9° | 55.1°-66.3° |
| αVβ3 liganded ectodomain (1L5G)† | — | — | — | — | 55.5°-66.6° |
| αIIbβ3 open headpiece‡ | — | — | — | — | 1.2°-12.3° |
| . | αIIbβ3closed headpiece* . | αIIbβ3 ectodomain (3FCS)* . | αVβ3 ectodomain (3IJE)† . | αVβ3 liganded ectodomain (1L5G)† . | αIIbβ3 open headpiece‡ . |
|---|---|---|---|---|---|
| αIIbβ3 closed headpiece* | 3.0° | 12.6°-13.3° | 11.5°-13.5° | 13.9°-15.9° | 51.3°-62.3° |
| αIIbβ3 ectodomain (3FCS)* | — | 0.2° | 7.4°-7.4° | 8.2°-8.3° | 57.9°-69.7° |
| αVβ3 ectodomain (3IJE)† | — | — | — | 1.9° | 55.1°-66.3° |
| αVβ3 liganded ectodomain (1L5G)† | — | — | — | — | 55.5°-66.6° |
| αIIbβ3 open headpiece‡ | — | — | — | — | 1.2°-12.3° |
Each pair of domains from 2 molecules was superposed using the β3 βI domain, and the change in angle upon superimposing the β3 hybrid domain was calculated.
— indicates duplicates or no comparison possible because only one structure is available.