Phenotypic abnormalities of LPA4-deficient embryos at E10.5, E12.5, E14.5, and E18.5
| E10.5 . | WT* . | KO* . |
|---|---|---|
| Mating | 6 | 5 |
| Total embryos | 53 (100)† | 50 (100) |
| Apparently normal embryos | 48 (90.6) | 36 (72.0) |
| Small and/or fragile embryos | 0 (0) | 2 (4.0) |
| Effusions and/or bleeding | 0 (0) | 7 (14.0) |
| Resorbed embryos | 5 (9.4) | 5 (10.0) |
| E12.5 | WT | KO |
| Mating | 12 | 9 |
| Total embryos | 106 (100) | 78 (100) |
| Apparently normal embryos | 95 (89.6) | 50 (64.1) |
| Small and/or fragile embryos | 0 (0) | 7 (9.0) |
| Retained placentas | 0 (0) | 10 (12.8) |
| Resorbed embryos | 11 (10.4) | 11 (14.1) |
| E14.5 | WT | KO |
| Mating | 17 | 14 |
| Total embryos | 147 (100) | 137 (100) |
| Apparently normal embryos | 133 (90.4) | 74 (54.0) |
| Edema and/or hemorrhage | 4 (2.8) | 26 (18.9) |
| Small and/or fragile embryos | 2 (1.4) | 4 (3.0) |
| Retained placentas | 0 (0) | 13 (9.5) |
| Resorbed embryos | 8 (5.4) | 20 (14.6) |
| E18.5 | WT | KO |
| Mating | 20 | 21 |
| Total embryos | 173 (100) | 181 (100) |
| Apparently normal embryos | 164 (94.8) | 90 (49.7) |
| Edema and/or hemorrhage | 0 (0) | 19 (10.5) |
| Agnathia or omphalocele | 0 (0) | 4 (2.2) |
| Macerated embryos | 0 (0) | 7 (3.9) |
| Retained placentas | 0 (0) | 20 (11.0) |
| Resorbed embryos | 9 (5.2) | 41 (22.7) |
| E10.5 . | WT* . | KO* . |
|---|---|---|
| Mating | 6 | 5 |
| Total embryos | 53 (100)† | 50 (100) |
| Apparently normal embryos | 48 (90.6) | 36 (72.0) |
| Small and/or fragile embryos | 0 (0) | 2 (4.0) |
| Effusions and/or bleeding | 0 (0) | 7 (14.0) |
| Resorbed embryos | 5 (9.4) | 5 (10.0) |
| E12.5 | WT | KO |
| Mating | 12 | 9 |
| Total embryos | 106 (100) | 78 (100) |
| Apparently normal embryos | 95 (89.6) | 50 (64.1) |
| Small and/or fragile embryos | 0 (0) | 7 (9.0) |
| Retained placentas | 0 (0) | 10 (12.8) |
| Resorbed embryos | 11 (10.4) | 11 (14.1) |
| E14.5 | WT | KO |
| Mating | 17 | 14 |
| Total embryos | 147 (100) | 137 (100) |
| Apparently normal embryos | 133 (90.4) | 74 (54.0) |
| Edema and/or hemorrhage | 4 (2.8) | 26 (18.9) |
| Small and/or fragile embryos | 2 (1.4) | 4 (3.0) |
| Retained placentas | 0 (0) | 13 (9.5) |
| Resorbed embryos | 8 (5.4) | 20 (14.6) |
| E18.5 | WT | KO |
| Mating | 20 | 21 |
| Total embryos | 173 (100) | 181 (100) |
| Apparently normal embryos | 164 (94.8) | 90 (49.7) |
| Edema and/or hemorrhage | 0 (0) | 19 (10.5) |
| Agnathia or omphalocele | 0 (0) | 4 (2.2) |
| Macerated embryos | 0 (0) | 7 (3.9) |
| Retained placentas | 0 (0) | 20 (11.0) |
| Resorbed embryos | 9 (5.2) | 41 (22.7) |