Table 3 Phenotypic similarities between... | American Society of Hematology

Table 3

Phenotypic similarities between mice deficient in LPA₄ and other molecules

Phenotypes of LPA₄-deficient mice	Molecules that cause similar phenotypes in mutants	Reported stages	Annotations	References
Abnormal blood vessels (hemorrhage) at E10.5-E18.5	TGF-β1	E9.5-E10.5	g	29
	ALK-1	E9.5-E10.5	a, e, f	30
	Endoglin	E9.5	a, e, f	31
	Smad5	E10.5-E11.5	b, e, f	32
	ATX	E8.5-E10.5	a, f	37, 38
	LPP3	E9.5-E10.5	f	40
	Endothelial Gα₁₃	E9.5-E11.5	a, f	41
	PAR1	E9.5-E10.5	a, g	43
	VEGFR3	E9.5	a, f	48
	GPR4	E10.5-postnatal	b, e, g	50
	S1P₁	E12.5-E14.5	e, f	47
	S1P_2/3	E13.5-E15.5	g	51
	PDGF-B	E17.5-E18.5	b, e, f	33
	PDGFRB	E16-prebirth	b, e, f	33, 34
Abnormal lymphatic vessels (edema) at E14.5-E18.5	Prox1	E14.5	f	23
	VEGFC	E15.5-E17.5	f	24
	Foxc2	E14.5-P1	c, d, e, f	25
	T1α/podoplanin	postnatal	c, f	26
	Angiopoietin-2	postnatal	c, e, g	27

Phenotypes of LPA₄-deficient mice	Molecules that cause similar phenotypes in mutants	Reported stages	Annotations	References
Abnormal blood vessels (hemorrhage) at E10.5-E18.5	TGF-β1	E9.5-E10.5	g	29
	ALK-1	E9.5-E10.5	a, e, f	30
	Endoglin	E9.5	a, e, f	31
	Smad5	E10.5-E11.5	b, e, f	32
	ATX	E8.5-E10.5	a, f	37, 38
	LPP3	E9.5-E10.5	f	40
	Endothelial Gα₁₃	E9.5-E11.5	a, f	41
	PAR1	E9.5-E10.5	a, g	43
	VEGFR3	E9.5	a, f	48
	GPR4	E10.5-postnatal	b, e, g	50
	S1P₁	E12.5-E14.5	e, f	47
	S1P_2/3	E13.5-E15.5	g	51
	PDGF-B	E17.5-E18.5	b, e, f	33
	PDGFRB	E16-prebirth	b, e, f	33, 34
Abnormal lymphatic vessels (edema) at E14.5-E18.5	Prox1	E14.5	f	23
	VEGFC	E15.5-E17.5	f	24
	Foxc2	E14.5-P1	c, d, e, f	25
	T1α/podoplanin	postnatal	c, f	26
	Angiopoietin-2	postnatal	c, e, g	27

, pericardial effusion at E9.5-E10.5;

, dilation of blood vessels;

, dilation of lymphatic vessels;

, dilation of lymph sacs;

, abnormal coverage of mural cells;

, full lethality; and

, partial lethality.