Table 4 Univariate and multivariate... | American Society of Hematology

Table 4

Univariate and multivariate analysis for risk factors predicting thrombotic events in follow-up (events, n = 27)

	Univariate analysis			Multivariate analysis
	HR	95% CI	P	HR	95% CI	P
Time elapsed from diagnosis (> 5 vs < 5 mo)	0.84	0.39-1.79	.65	0.85	0.39-1.85	.68
Sex (male vs female)	0.89	0.39-1.98	.77	0.89	0.39-2.02	.78
Age > 60 y	2.37	0.97-5.78	.06	2.99	1.19-7.51	.02
Previous thrombosis	3.23	1.45-7.18	.004	3.63	1.61-8.16	.002
JAK2V617F	1.17	0.51-2.71	.71	0.96	0.34-2.46	.94
Response to HU
CR	1 (ref)
PR	1.38	0.62-3.10	.43	5.08	0.65-16	.12
No response	1.00	0.35-2.45	.87	4.47	0.45-25	.20
*PLT, ×10⁹/L**
Less than 400	1 (ref)			1 (ref)
More than 400	1.04	0.39-2.74	.95	0.24	0.04-1.58	.14
WBC, ×10⁹/L
Less than 10	1 (ref)			1 (ref)
More than 10	2.85	1.27-6.39	.01	2.86	1.23-6.66	.015

	Univariate analysis			Multivariate analysis
	HR	95% CI	P	HR	95% CI	P
Time elapsed from diagnosis (> 5 vs < 5 mo)	0.84	0.39-1.79	.65	0.85	0.39-1.85	.68
Sex (male vs female)	0.89	0.39-1.98	.77	0.89	0.39-2.02	.78
Age > 60 y	2.37	0.97-5.78	.06	2.99	1.19-7.51	.02
Previous thrombosis	3.23	1.45-7.18	.004	3.63	1.61-8.16	.002
JAK2V617F	1.17	0.51-2.71	.71	0.96	0.34-2.46	.94
Response to HU
CR	1 (ref)
PR	1.38	0.62-3.10	.43	5.08	0.65-16	.12
No response	1.00	0.35-2.45	.87	4.47	0.45-25	.20
*PLT, ×10⁹/L**
Less than 400	1 (ref)			1 (ref)
More than 400	1.04	0.39-2.74	.95	0.24	0.04-1.58	.14
WBC, ×10⁹/L
Less than 10	1 (ref)			1 (ref)
More than 10	2.85	1.27-6.39	.01	2.86	1.23-6.66	.015

Variables at 12 months of HU treatment. PLT indicates platelets.

For PLT > 600 × 10⁹/L; hazard ratio = 1.05; P = .91.