Table 1

Demographic and clinical characteristics at diagnosis of 106 patients with JAK2 exon 12-mutated polycythemia vera

CharacteristicValue
Age, y (n = 106)  
    Median 52 
    Range 15-92 
Sex (n = 106)  
    Male 57 (54%) 
    Female 49 (46%) 
Hemoglobin, g/dL (n = 106)  
    Median 19.3 
    Range 16.6-25.0 
WBC count, × 109/L (n = 106)  
    Median 7.6 
    Range 4.2-21.0 
Platelets, × 109/L (n = 106)  
    Median 293 
    Range 132-1590 
Cardiovascular risk factor* (n = 89) 55 (61%) 
Splenomegaly (n = 73) 17 (23%) 
Prior thrombosis (n = 86) 13 (15%) 
Subnormal serum erythropoietin (n = 77) 73 (95%) 
Endogenous erythroid colonies (n = 42)  
    Present 35 (83%) 
    Absent 7 (17%) 
Bone marrow histology/trephine (n = 42)  
    Normal cellularity (age-related7 (17%) 
    Increased cellularity (age-related35 (83%) 
Karyotype (n = 45)  
    Normal 40 (89%) 
    Abnormal§ 5 (11%) 
Familial cases 3 (3%) 
CharacteristicValue
Age, y (n = 106)  
    Median 52 
    Range 15-92 
Sex (n = 106)  
    Male 57 (54%) 
    Female 49 (46%) 
Hemoglobin, g/dL (n = 106)  
    Median 19.3 
    Range 16.6-25.0 
WBC count, × 109/L (n = 106)  
    Median 7.6 
    Range 4.2-21.0 
Platelets, × 109/L (n = 106)  
    Median 293 
    Range 132-1590 
Cardiovascular risk factor* (n = 89) 55 (61%) 
Splenomegaly (n = 73) 17 (23%) 
Prior thrombosis (n = 86) 13 (15%) 
Subnormal serum erythropoietin (n = 77) 73 (95%) 
Endogenous erythroid colonies (n = 42)  
    Present 35 (83%) 
    Absent 7 (17%) 
Bone marrow histology/trephine (n = 42)  
    Normal cellularity (age-related7 (17%) 
    Increased cellularity (age-related35 (83%) 
Karyotype (n = 45)  
    Normal 40 (89%) 
    Abnormal§ 5 (11%) 
Familial cases 3 (3%) 
*

Smoking, arterial hypertension, diabetes, hypercholesterolemia and hypertriglyceridemia/dyslipidemia, and acquired or congenital thrombophilia were considered as cardiovascular risk factors.

Splenomegaly was assessed by palpation.

According to EUMNET criteria.

§

Abnormal as follows: 45, X,−Y; 46, XX, del(20p)/47, XX, del(20p),+14; 47, XY,+9; 46, XX, del(20q); 47, XX,+9.

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