Demographic and clinical characteristics at diagnosis of 106 patients with JAK2 exon 12-mutated polycythemia vera
Characteristic . | Value . |
---|---|
Age, y (n = 106) | |
Median | 52 |
Range | 15-92 |
Sex (n = 106) | |
Male | 57 (54%) |
Female | 49 (46%) |
Hemoglobin, g/dL (n = 106) | |
Median | 19.3 |
Range | 16.6-25.0 |
WBC count, × 109/L (n = 106) | |
Median | 7.6 |
Range | 4.2-21.0 |
Platelets, × 109/L (n = 106) | |
Median | 293 |
Range | 132-1590 |
Cardiovascular risk factor* (n = 89) | 55 (61%) |
Splenomegaly (n = 73)† | 17 (23%) |
Prior thrombosis (n = 86) | 13 (15%) |
Subnormal serum erythropoietin (n = 77) | 73 (95%) |
Endogenous erythroid colonies (n = 42) | |
Present | 35 (83%) |
Absent | 7 (17%) |
Bone marrow histology/trephine (n = 42) | |
Normal cellularity (age-related‡) | 7 (17%) |
Increased cellularity (age-related‡) | 35 (83%) |
Karyotype (n = 45) | |
Normal | 40 (89%) |
Abnormal§ | 5 (11%) |
Familial cases | 3 (3%) |
Characteristic . | Value . |
---|---|
Age, y (n = 106) | |
Median | 52 |
Range | 15-92 |
Sex (n = 106) | |
Male | 57 (54%) |
Female | 49 (46%) |
Hemoglobin, g/dL (n = 106) | |
Median | 19.3 |
Range | 16.6-25.0 |
WBC count, × 109/L (n = 106) | |
Median | 7.6 |
Range | 4.2-21.0 |
Platelets, × 109/L (n = 106) | |
Median | 293 |
Range | 132-1590 |
Cardiovascular risk factor* (n = 89) | 55 (61%) |
Splenomegaly (n = 73)† | 17 (23%) |
Prior thrombosis (n = 86) | 13 (15%) |
Subnormal serum erythropoietin (n = 77) | 73 (95%) |
Endogenous erythroid colonies (n = 42) | |
Present | 35 (83%) |
Absent | 7 (17%) |
Bone marrow histology/trephine (n = 42) | |
Normal cellularity (age-related‡) | 7 (17%) |
Increased cellularity (age-related‡) | 35 (83%) |
Karyotype (n = 45) | |
Normal | 40 (89%) |
Abnormal§ | 5 (11%) |
Familial cases | 3 (3%) |
Smoking, arterial hypertension, diabetes, hypercholesterolemia and hypertriglyceridemia/dyslipidemia, and acquired or congenital thrombophilia were considered as cardiovascular risk factors.
Splenomegaly was assessed by palpation.
According to EUMNET criteria.
Abnormal as follows: 45, X,−Y; 46, XX, del(20p)/47, XX, del(20p),+14; 47, XY,+9; 46, XX, del(20q); 47, XX,+9.