Five-year cumulative risk and rate ratios of a hospitalized intracranial bleeding episode among 407 patients with cITP and 4069 members of the general population comparison cohort
| . | Five-year risk among patients with cITP, % (95% CI) . | Five-year risk in the comparison cohort, % (95% CI) . | Crude 5-year RR (95% CI) . | Adjusted 5-year RR (95% CI)* . |
|---|---|---|---|---|
| Total | 1.4 (0.5-3.2) | 0.6 (0.3-0.9) | 2.8 (1.0-7.5) | 3.2 (1.2-9.0) |
| Age at cITP diagnosis, y | ||||
| ≤ 60 | 0.4 (0.0-2.3) | 0.1 (0.0-0.3) | 5.1 (0.5-56.0) | 5.0 (0.5-55.1) |
| > 60 | 2.6 (0.8-6.1) | 1.1 (0.7-1.8) | 2.7 (0.9-7.9) | 3.0 (1.0-9.2) |
| Sex | ||||
| Female | 1.9 (0.6-4.5) | 0.3 (0.2-0.7) | 6.0 (1.8-20.4) | 12.3 (2.8-55.2) |
| Male | 0.7 (0.1-3.3) | 0.9 (0.5-1.8) | 0.9 (0.1-6.9) | 0.8 (0.1-6.3) |
| Year of cITP diagnosis | ||||
| 1996-2001 | 1.2 (0.2-3.9) | 0.3 (0.1-0.7) | 4.2 (0.8-21.6) | 9.2 (1.3-65.5) |
| 2002-2007 | 1.7 (0.4-4.8) | 0.8 (0.4-1.3) | 2.3 (0.7-8.0) | 2.2 (0.6-8.0) |
| Comorbidity score | ||||
| 0 | 0.9 (0.2-3.2) | 0.04 (0.0-0.3) | 20.3 (1.8-223.7) | 18.6 (1.7-205.7) |
| ≥ 1 | 2.3 (0.6-6.1) | 1.4 (0.8-2.2) | 1.9 (0.6-6.5) | 2.1 (0.6-7.3) |
| . | Five-year risk among patients with cITP, % (95% CI) . | Five-year risk in the comparison cohort, % (95% CI) . | Crude 5-year RR (95% CI) . | Adjusted 5-year RR (95% CI)* . |
|---|---|---|---|---|
| Total | 1.4 (0.5-3.2) | 0.6 (0.3-0.9) | 2.8 (1.0-7.5) | 3.2 (1.2-9.0) |
| Age at cITP diagnosis, y | ||||
| ≤ 60 | 0.4 (0.0-2.3) | 0.1 (0.0-0.3) | 5.1 (0.5-56.0) | 5.0 (0.5-55.1) |
| > 60 | 2.6 (0.8-6.1) | 1.1 (0.7-1.8) | 2.7 (0.9-7.9) | 3.0 (1.0-9.2) |
| Sex | ||||
| Female | 1.9 (0.6-4.5) | 0.3 (0.2-0.7) | 6.0 (1.8-20.4) | 12.3 (2.8-55.2) |
| Male | 0.7 (0.1-3.3) | 0.9 (0.5-1.8) | 0.9 (0.1-6.9) | 0.8 (0.1-6.3) |
| Year of cITP diagnosis | ||||
| 1996-2001 | 1.2 (0.2-3.9) | 0.3 (0.1-0.7) | 4.2 (0.8-21.6) | 9.2 (1.3-65.5) |
| 2002-2007 | 1.7 (0.4-4.8) | 0.8 (0.4-1.3) | 2.3 (0.7-8.0) | 2.2 (0.6-8.0) |
| Comorbidity score | ||||
| 0 | 0.9 (0.2-3.2) | 0.04 (0.0-0.3) | 20.3 (1.8-223.7) | 18.6 (1.7-205.7) |
| ≥ 1 | 2.3 (0.6-6.1) | 1.4 (0.8-2.2) | 1.9 (0.6-6.5) | 2.1 (0.6-7.3) |
cITP indicates chronic immune thrombocytopenia; CI, confidence interval; and RR, rate ratio.
Adjusted for age (≤ 60 y and > 60 y), sex, calendar year, and level of comorbidity.